Human Cytochrome P450 Enzymes

Abelo A, Andersson TB, Antonsson M et al (2000) Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metab Dispos 28 966-972... 

Rendic, S. DiCarlo, F. J. (1997). Human cytochrome P450 enzymes a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab. Rev., 29, 413-580. 

Ingelman-Sundberg M, Oscarson M, McLelian RA. Polymorphic human cytochrome P450 enzymes an opportunity for individualized dmg treatment. Trends Pharmacol Sci 1999 20 342-349. 

Trubetskoy, O.V., Gibson, J.R., and Marks, B.D. 2005. Highly miniaturized formats for in vitro drug metabolism assays using vivid fluorescent substrates and recombinant human cytochrome P450 enzymes. J. Biomol. Screen. 10 56. 

Testino, A.S., Jr. and Patonay, G. 2003. High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography/tandem mass spectrometry. J. Pharm. Biomed. Anal. 30 1459. 

Duffy JE, Hay ME (2001) The ecology and evolution of marine consumer-prey interactions. In Bertness MD, Gaines SD, Hay ME (eds) Marine community ecology. Sinauer, Sunderland, pp 131-158 Duisken M, Sandner F, Blomeke B, Hollender J (2005) Metabolism of 1,8-cineole by human cytochrome P450 enzymes identification of a new hydroxylated metabolite. Biochim Biophys Acta 1722 304-311... 

Yamazaki, H., Suzuki, M., Tane, K., Shimada, N., Nakajima, M. and Yokoi, T. (2000) in vitro inhibitory effects of troglitazone and its metabolites on drug oxidation activities of human cytochrome P450 enzymes comparison with pioglitazone and rosiglitazone. Xenobiotica, 30 (1), 61—70. 

Atkinson, A., Kenny, J.R. and Grime, K. (2005) Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis. Drug Metabolism and Disposition, 33 (11), 1637—1647. 

Obach, R.S., Walsky, R.L. and Venkatakrishnan, K. (2007) Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions. Drug Metabolism and Disposition, 35 (2), 246—255. 

Liu Y, Zhang IW, Li W et al (2006) Ginsenoside metabohtes, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. 1 Toxicol Sd 91 356-364... 

Verhoeven CHJ, Vos RME, Bogaards JJP. Characterization and inhibition of human cytochrome P450 enzymes involved in the in vitro metabolism of mirtazapine. Presentation at International Symposium on Microsomes and Drug Oxidations, Los Angeles, July 21-24, 1996. 

Ginseng Much ado about nothing Consumer Reports, Nov. 1995 699. Obach RS. Inhibition of human cytochrome P450 enzymes by constituents of St. John s wort s, an herbal preparation used in the treatment of depression. J Pharmacol Expl Ther 2000 294 88-95. 

Guengerich FP Human cytochrome P450 enzymes. In Ortiz de Montellano P (editor). Cytochrome P450 Structure, Mechanism and Biochemistry, 3rd ed. Kluwer-Academic/Plenum Press, 2005. 

Kirkwood LC et al Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine. Br 3 Clin Pharmacol 1997 44 549. [PMID 9431830]... 

Guengerich FP. Catalytic selectivity of human cytochrome P450 enzymes relevance to drug metabolism and toxicity. Toxicol Lett 1994 70 133-138. 

Bogaards, J.J.P., Vanekamp, J.C. van Bladeren, P.J. (1996) The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes. Chem-biol. Interact., 102, 169-182... 

F.P. Guengerich, Human Cytochrome P450 Enzymes , in Cytochrome P450 - Structure, Mechanism, and Biochemistry, 2nd edition, ed. P.R. Ortiz de Montellano, Plenum Press, New York, 473-517,1995. 

Crewe HK et al (2002) Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes formation of the 4-hydroxy, 4 -hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos 30 869-874... 

Kinzig-Schippers M, Fuhr U, Zaigler U, et al. Interaction of pefloxacin and enox-acin with the human cytochrome P450 enzyme CYP1A2. Clin Pharmacol Ther 1999 65 262-274. 

Katoh M, Nakajima M, Shimada N, et al. Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol 2000 55 843-852. 

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