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CYP inhibition screen

H. and Pelkonen, O. (2006) Cytochrome P450 (CYP) inhibition screening comparison of three tests. European... [Pg.238]

LC/MS/MS with selected reaction monitoring (SRM) offers a fast and simple means to analyze biological matrices, which is a key factor in high-throughput CYP inhibition screens using liver microsomes. Potentially, the LC/MS/MS technique is suitable for analyses of cocktail substrates in other in vitro drug metabolism evaluations such as CYP induction/activation assays, rapid analysis of pooled liver microsomes, rapid reaction phenotyping of tissue (hepatic and extrahepatic) samples, as well as evaluation of hepatocytes/tissue slice CYP activity. ° ... [Pg.427]

Bu, H.Z., Magis, L, Knuth, K. and Teitelbaum, P. (2001) High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing... [Pg.191]

The RapidFire method is well-suited to smdies such as CYP inhibition screening and for monitoring any enzymatic reaction, because the same substrate/product pair is monitored for each incubation. Thus, it is possible to optimize the on-line SPE/MS/MS method for each specific product formed from an enzymatic assay. For studies requiring evaluation of the appearance/disappearance of the test compound (e.g., metabolic stability screening), an optimized SPE/MS/MS method for each compound must be developed, which may present challenges if the analytes being evaluated have substantially different physicochemical properties. [Pg.817]

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See also in sourсe #XX -- [ Pg.170 ]



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