Human Cdc2 kinase

Liu, F., Stanton, J. J., Wu, Z., Piwnica-Worms, H. (1997). The human Mytl kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Molecular and Cellular Biology, 17, 571—583. 

Johnson, K.W. Smith, K.A. Molecular cloning of a novel human cdc2/ CDC28-like protein kinase. J. Biol. Chem., 266, 3402-3407 (1991)... 

Brizuela, L., G. Draetta D. Beach. 1989. Activation of human CDC2 protein as a histone HI kinase is associated with complex formation with the p62 subunit. Proc. Natl. Acad. Sci. USA 86 4362-6. 

Shi L et al (1996) Granzyme B induces apoptosis and cyclin A-associated cyclin-dependent kinase activity in all stages of the cell cycle. J Immunol 157 2381-2385 Shimizu T et al (1995) Unscheduled activation of cyclin Bl/ Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage. Cancer Res 55 228-231... 

Draetta, G., and Beach, D. (1988). Activation of cdc2 protein kinase during mitosis in human cells cell cycle-dependent phosphorylation and subunit rearrangement. Cell 54 17-24. 

Ross-Macdonald PB, Graeser R, Kappes B et al (1994) Isolation and expression of a gene specifying a cdc2-like protein kinase from the human malaria parasite Plasmodium falciparum. Eur J Biochem 220(3) 693-701... 

Booher, R. N., Holman, P. S., Fattaey, A. (1997). Human Mytl is a cell cycle-regulated kinase that inhibits CDC2 but not CDK2 activity. The Journal of Biological Chemistry, 272, 22300-22306. 

Promotes growth arrest at G2/M induction of GADD45 phosphorylation and inactivation of the cell-cycle kinase, cdc2 Promotes DNA human... 

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