Human calcium absorption various effects

Bioavailability of triamterene has been studied in healthy human subjects.59 62 65 79 The bioavailability of triamterene was found to be 52%, corresponding to absorption of 83%, in a study done in six volunteers after intravenous administration of the drug.62 Another study reported that triamterene bioavailability from capsules was poorer and more variable than that from suspension.65 Effect of various vehicles and vehicle volumes on oral bioavailability of triamterene has been investigated.80 Addition of a combination of a surfactant and carbonate or bicarbonate as diluents to a triamterene gelatin capsule is reported to result in better bioavailability of the drug.81 When both calcium carbonate and cetylpyridinium chloride were present in a triamterene capsule the dissolution rates were greatly increased over triamterene capsules containing neither diluent or either... 

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