Human brain effects

Bray, N.J., Jehu, L., Moskvina, V., et al. (2004) Allelic expression of APOE in human brain effects of epsilon status and promoter haplotypes. Hum. Mol. Genet., 13, 2885-2892. 

Harrison PJ, Procter AW, Exworthy T, Robert GW, Najlerahim A, et al. 1993. Heat shock protein Chsp70) mRNA expression in human brain Effects of neurodegenerative disease and agonal state. Neuropathol Appl Neurobiol 19 10-21. 

Patel, M.S., Grover, W.D. and Auerbach, V.H. (1973), Pyruvate metabolism in homogenates of human brain effects of phenylpyruvate and implications for the etiology of the mental retardation in phenylketonuria. J. Neurochem., 20,289. 

Since the early 20th century, chemists have represented molecular information by molecular models. The human brain comprehends these representations of graphical models with 3D relationships more effectively than numerical data of distances and angles in tabular form. Thus, visualization makes complex information accessible to human understanding easily and directly through the use of images. 

Consider the basic probkun of how information is distributed throughout a system, and the manner in which it is retrieved. We. know that in a conventional computer, for example, information is stored in random-access memory (RAM). This means that the memory address of where the information actually exists and the information itself are uncorrelated. In order to retrieve the information, one must know its address exactly, as even the slightest error renders that information effectively unretrievable. In particular, it is in general impossible to retrieve RAM data if armed only with a partial knowledge of its address. In contrast, associative memories (sometimes also called content-addressable memories), much like the form of memory believed to be used by human brains, are such that they can be completely retrieved even when searched for with partial information,... 

Hi-receptors in the adrenal medulla stimulates the release of the two catecholamines noradrenaline and adrenaline as well as enkephalins. In the heart, histamine produces negative inotropic effects via Hr receptor stimulation, but these are normally masked by the positive effects of H2-receptor stimulation on heart rate and force of contraction. Histamine Hi-receptors are widely distributed in human brain and highest densities are found in neocortex, hippocampus, nucleus accumbens, thalamus and posterior hypothalamus where they predominantly excite neuronal activity. Histamine Hrreceptor stimulation can also activate peripheral sensory nerve endings leading to itching and a surrounding vasodilatation ( flare ) due to an axonal reflex and the consequent release of peptide neurotransmitters from collateral nerve endings. 

As early as 1961, the first generation of MAO inhibitors (iproniazid, isocarboxazide) were employed for the treatment of Parkinson s disease (PD). However, because of the severe side effects, such as cheese reaction, they were abandoned. The realization that the basal ganglia (extrapyramidal region) of human brain contained mostly MAO-B, which metabolized... 

Anton-Tay, F., Diaz, J. L. 8r Fernandez-Guardiola, A. (1971). On the effect of melatonin upon human brain. Its possible therapeutic imphcations. Life Sci. [I] 10, 841-50. 

METH-Induced Effects in Human Brain Imaging Studies.65... 

Meador-Woodruff J., Little K., Damask S., Mansour P., Watson S. Effects of cocaine on dopamine receptor gene expression A study in the postmortem human brain. Biol. Psychiatry. 34 348, 1993. 

Moore GJ, Hasanat K, Chen G, Seraji-Bozorgzad N, Wilds IB, Faulk MW, Koch S, Jolkovsky L, Manji HK. Lithium Increases N-Acetyl-Aspartate in the Human Brain In Vivo Evidence in Support of bcl-2 s Neurotrophic Effects. Biol Psychiatry 2000 48 1-8. 

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