Human barrier analysis information

As the density of information derived from efforts to sequence, map and identify human genes increased, so did the demand for analytical tools capable of exploiting this information. DNA microarrays were developed in response to this demand. Southern(69) was the first to describe parallel, in situ ohgonucleotide synthesis as a means of generating oligonucleotide probe arrays on solid supports for highly parallel hybridization analysis. Southern s method uses standard nucleotide synthetic reactions to synthesize the oligonucleotides. The reactions are carried out in a movable chamber, which provides a physical barrier between the reaction chamber and the intended synthesis area. 

Accelerated development schemes have made scientists more dependent on analytical information, and consequently, they are more apt to want to control or perform analysis activities themselves. No doubt the human factor will inevitably arise and create reluctance, and perhaps, barriers to adopt new approaches. For example, the LC/MS applications that deal with open-access support for combinatorial and medicinal chemistry made aspects of acceptance quite clear. A chemist preferred simple answers to simple questions. 

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