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5-HT6 receptor antagonists

D. R. Bicyclic piperazinylbenzenesulfona-mides are potent and selective 5-HT6 receptor antagonists. Bioorg. Med. Chem. Lett. 2002, 22, 1357-1360. [Pg.256]

Bromidge SM, Brown AM, Clarke SE, et al. 5-Chloro-A-(4-methoxy-3-piperazin-l-ylphenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046) a potent, selective, and orally bioavailable 5-HT6 receptor antagonist. J Med Chem 1999 42 202-205. [Pg.141]

Riemer C, Borroni E, Levet-Trafit B, et al. Influence of the 5-HT6 receptor on acetylcholine release in the cortex pharmacological characterization of 4-(2-bromo-6-pyrrolidin-l-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. J Med Chem 2003 46 1273-1276. [Pg.203]

Roberts JC, Reavill C, East SZ, et al. The distribution of 5-HT6 receptors in rat brain an autoradiographic binding study using the radiolabelled 5-HT6 receptor antagonist [12SI]SB-258585. Brain Res 2002 934 49-57. [Pg.363]

Lindner MD, Hodges DB Jr, Hogan JB, et al. An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning. J Pharmacol Exp Ther 2003 307 682-691. [Pg.433]

Rogers DC, Hagan JJ. 5-HT6 receptor antagonists enhance retention of a water maze task in the rat. Psychopharmacology (Berl) 2001 158 114-119. [Pg.433]

Leng A, Ouagazzal A, Feldon J, Higgins GA. Effect of the 5-HT6 receptor antagonists Ro04-6790 and Ro65-7199 on latent inhibition and prepulse inhibition in the rat comparison to clozapine. Pharmacol Biochem Behav 2003 75 281-288. [Pg.433]

Minabe Y, Shirayama Y, Hashimoto K, Routledge C, Hagan JJ, Ashby CR Jr. Effect of the acute and chronic administration of the selective 5-HT6 receptor antagonist SB-271046 on the activity of midbrain dopamine neurons in rats an in vivo electrophysiological study. Synapse 2004 52 20-28. [Pg.494]

The 5-ht6 receptor antagonists R065-7199, R065-7674, and R004-6790 (34,36-38) increase acetylcholine levels in the hippocampus and the cortex (35). [Pg.496]

Potential of 5-ht6 Receptor Antagonists for the Treatment of Cognitive Deficits in Schizophrenia... [Pg.498]

Routledge C, Bromidge SM, Moss SF, et al. Characterization of SB-271046 A potent, selective and orally active 5-HT6 receptor antagonist Br J Pharmacol 2000 130 1606-1612. [Pg.509]

Bos M, Sleight AJ, Godel T, Martin JR, Riemer C, Stadler H. 5-HT6 receptor antagonists lead optimisation and biological evaluation of V-aryl and. Y-hctcroaryl 4-amino-benzene sulfonamides. Eur J Med Chem 2001 36 165-178. [Pg.510]

Dawson LA, Nguyen HQ, Li P. The 5-HT6 receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus. Neuropsychopharmacology 2001 25 662-668. [Pg.510]

Woolley ML, Marsden CA, Sleight AJ, Fone KCF. Reversal of a cholinergic-induced deficit of recognition memory by the selective 5-ht6 receptor antagonist, Ro 04-6790. Psychopharmacology 2003 170 358-367. [Pg.511]

Lacroix LP, Dawson LA, Hagan JJ, Heidbreder CA. 5-HT6 receptor antagonist SB-271046 enhances extracellular levels of monamines in rat medial prefrontal cortex. Synapse 2004 51 158-164. [Pg.511]

Lieben CKJ, Blokland A, Sik A, Sung E, van Nieuwenhuizen P, Schreiber R. The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat. Neuropsychopharmacology 2005 30(12) 2169-2179. [Pg.511]

Pouzet B, Didriksen M, Amt J. The antipsychotic potential of the 5-HT6 receptor antagonist SB-271046 in rats. Behav Pharmacol 2001 12 S80. [Pg.511]

Szczpanski K, Vivian JA, Dorsch K, et al. Procognitive effects of the 5-HT6 receptor antagonist R04368554, Soc Neurosci Abstr 2002 28 290.20. [Pg.512]

Stean TO, Hirst WD, Thomas DR, et al. Pharmacological profile of SB-357134 a potent, selective, brain penetrant, and orally active 5-HT6 receptor antagonist. Pharmacol Biochem Behav 2002 71 645-654. [Pg.512]

Hatcher PD, Brown VJ, Tait DS, Bate S, Overend P, Hagan JJ, Jones DNC. 5-HT6 receptor antagonists improve performance in an attentional set shifting task in rats. Psychopharmacology 2005 181 259-269. [Pg.513]

Wolff MC, Overshiner C, Leander JD. 5-HT6 receptor antagonists enhance memory in radial maze and object recognition tasks. Soc Neurosci Abstr 2002 28 586.1. [Pg.514]

See other pages where 5-HT6 receptor antagonists is mentioned: [Pg.1125]    [Pg.261]    [Pg.374]    [Pg.345]    [Pg.420]    [Pg.490]    [Pg.495]    [Pg.497]    [Pg.497]    [Pg.498]    [Pg.498]    [Pg.500]    [Pg.500]    [Pg.501]    [Pg.501]    [Pg.502]    [Pg.502]    [Pg.503]    [Pg.505]    [Pg.505]    [Pg.506]    [Pg.506]    [Pg.507]    [Pg.507]    [Pg.507]    [Pg.508]   
See also in sourсe #XX -- [ Pg.98 ]



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5-HT6 receptor

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