Hovea

Lamberton, J. A., Morton, T. C. and Suares, H. 1982. Alkaloids of Hovea linearis R.Br. The isolation of Ormosia group alkaloids. Australian Journal of Chemistry, 35 2577. 

Another set of weak Icmt inhibitors from natural sources were also discovered by Buchanan and coworkers [75]. Prenylated p-hydroxy chal-cone derivatives along with the known flavone, (5)-glabrol, were discovered from the extract Hovea parvicalyx and found to possess Icmt inhibitory activity with an IC50 of 17 pM. Interesting to note that the p-hydroxychal-cones have a structural resemblance to some metal chelators. Continued studies on these natural products will further give the medicinal chemist insight into the continued refinement of Icmt inhibitors. 

Buchanan, M.S., et al (2008). Small-molecule inhibitors of the cancer target, isoprenylcysteine carboxyl methyltransferase, from Hovea parvicalyx. Phytochemistry 69 1886-1889. 

Ormosia Group.—Alkaloids of this type have been isolated for the first time from Hovea species. H. linearis contains ( )-piptanthine and ( )-16-epiormosanine,... 

A complex dipiperidine alkaloid (-)-baptifoline (20) occurs in the Leguminous plant Hovea longipes indigenous to Australia (J.S. Fitzgerald et al., Anales de Quim., 1972, 68, 737) and the unnamed amide (21) is found in the stem bark of Exoecharia sagallocha (S. Prakash et al, Phytochem., 1983,... 

A number of unusual quinolizidine alkaloids have been isolated from various leguminous plants now classified in the Fabaceae, such as lamprolobine (59) from Lamprolobium fruticosum 182], and podopetaline (60), a new member of the Ormosia group of alkaloids that was isolated from Podopetalum ormondii [831. Other genera, including Templetonia and Hovea, have been found to produce well-known leguminous alkaloids such... 

The leaves and terminal branches of the Western Australian blue bush , Hovea elliptica (Sm.) DC., contain (+ )-sparteine (1), ( -)-lupanine (2), (— )-anagyrine (3), and ( —)-cytisine (4)T The major alkaloid of the seeds is (— )-cytisine. The co-occurrence of these four alkaloids lends credence to Robinson s proposal, as modified by Leete, that cytisine is formed in vivo by oxidative degradation of sparteine, via lupanine and anagyrine. Rhombifoline (5), the missing link in this sequence, has not so far been detected in this species. 

FIGURE 54.21 The structure of PEOVE-f>-P(HOVEA EM) synthesized by living cationic polymerization. 

D) Mobilization begins at centre of cotyledon Piptanthus laburnifo-Hus Hovea trisperma + other species not recorded Phaseolus vulgaris P. lunatus Vigna sinensis Dolichos lablab... 

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