Growth hormone receptor antagonists

Pegvisomant is a growth hormone receptor antagonist registered for the treatment of patients with acromegaly who had insufficient benefit from surgery or radiation. [Pg.389]

Trainer PJ, Drake WM, Katznelson L, et al. Treatment of acromegaly with the growth hormone-receptor antagonist Pegvisomant. N Engl J Med 2000 342 1171-1177. [Pg.1422]

Van Der Lely AJ, Hutson R, Trainer PJ, et al. Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist. Lancet 2001 358 1754-1759. [Pg.1422]

Kopchick, J.J., Parkinson, C., Stevens, E.C., Trainer, P.J. Growth hormone receptor antagonists discovery, development, and use in patients with acromegaly, Endocr. Rev. 23, 623-646, 2002. [Pg.1417]

N. Doyle, M.J. Waters et al. (2001). Binding and functional studies with the growth hormone receptor antagonist, B2036-PEG (pegvisomant), reveal effects of pegylation and evidence that it binds to a receptor dimer. J. Clin. Endocrinol. Metab. 86, 1716-1723. [Pg.371]

Thirone, AC, Scarlett, JA, Gasparetti, AL, Araujo, EP, Lima, MH, Carvalho, CR, Velloso, LA, and Saad, MJ, Modulation of growth hormone signal transduction in kidneys of streptozotocin-induced diabetic animals effect of a growth hormone receptor antagonist. Diabetes, 2002. 51(7) 2270-2281. [Pg.39]

Growth hormone receptor antagonists [SEDa-31, 707 seda-32, 794 SEDA-33, 911]... [Pg.708]

Growth hormone receptor antagonists [SEDA-30, 510 SEDA-31, 707 SEDA-32, 794]... [Pg.911]

Goldenberg N, Racine MS, Thomas P, Degnan B, Chandler W, Barkan A. Treatment of pituitary gigantism with the growth hormone receptor antagonist pegvisomant. J Clin Endocrinol Metab 2008 93 2953-6. [Pg.918]

GROWTH HORMONE RECEPTOR ANTAGONISTS fSEDA-33, 911 SEDA-34, 708 SEDA-35, 792] ... [Pg.664]

Somavert [25, 26] PEGylated growth hormone receptor antagonist Acromegaly 2003... [Pg.34]

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