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Hormones antagonistic actions

Tumors derived from hormone sensitive tissues may remain hormone dependent and are then amenable to therapeutic approaches with hormonal agents. These include hormones with opposing (apoptotic) action, hormone antagonists, and agents that inhibit hormone synthesis. [Pg.155]

Flototto, T. Djahansouzi, S. Glaser, M. Hanstein, B. Niederacher, D. Brumm, C. Beckmann, M. W. Hormones and hormone antagonists mechanisms of action in carcinogenesis of endometrial and breast cancer. Horm. Metab. Res. 2001, 33, 451 -57. [Pg.355]

Propylthiouracil [PTU] [Antithyroid Agent/Thyroid Hormone Antagonist] Uses HypCTthyroidism Action X Production of Tg T4 conversion of T4 to Tg Dose Adults. Initial 100 mg PO q8h (may need up... [Pg.267]

One of the principles of the use of hormones in oncology is based on the fact that the growth of tumors which occur in hormone-sensitive tissues may be inhibited by hormones with opposing actions, by hormone antagonists, or by agents that inhibit the synthesis of the stimulatory hormone. Other hormone treatments are based on less specific antimitotic effects. [Pg.457]

Between the mid-1970s and the mid-1980s, Schering AG carried out a project to develop a compound which had a much higher antagonistic action than that of spironolactone, as well as a lesser sex organ-specific action, since chronic treatment and high doses of spironolactone had caused hormonal disorders in both women and men. [Pg.396]

Lim, W., N.-H. Nguyen, H.Y. Yang, T.S. Scanlan and J.D. Furlow. A thyroid hormone antagonist that inhibits thyroid hormone action in vivo. J. Biol. Chem. 277 35664-35670, 2002. [Pg.412]

Enhancement of diuretic hormone actions could be fatal for those insects that have critical problems of maintaining body water, esp. soft-bodied larvae. Soft-bodied larvae rely on hemolymph volume to maintain turgor for movement, and dehydration would result in immobility followed by death, inhibition of antidiuretic hormones could have serious effects on insects that reside in extremely dry environments, e.g. stored grain. Antidiuretic hormone antagonists in combination with diuretic hormone agonists would be especially potent. [Pg.149]

Hormones are used specifically in cancers that are hormone dependent. Growth of such tumours can be suppressed by hormones with the opposite action, by hormone antagonists or by inhibition of hormone secretion. [Pg.185]

Ethyl-4-[2-(t-butylcarbonyloxy)butoxy] benzoate (ETB, ZR-2646, 71) occupies an intermediate position between the juvenile hormone mimics and the antijuvenile hormones to be discussed later. It acts as an anti-JH at low doses and as a JH mimic at high doses. The nature of this JH agonist/antagonist action is not understood, yet its interference with the induction of juvenile hormone esterase seems to elucidate at least partly its action on insects (Staal, 1977 Sparks et al., 1979). [Pg.191]

Other processes involve an antagonistic action of auxin vs. cytokinin as well. For example, studies with transgenic plants containing genes for enhanced synthesis of either auxin or cytokinin has shown that both apical dominance and xylem development depend on the relative amounts of these hormones [32]. Enhanced auxin increases apical dominance and xylem formation, while enhanced endogenous cytokinin promotes the outgrowth of lateral buds, leading to a more branched plant, and decreased xylem development. [Pg.12]

Typical of juvenile hormone antagonists are the precocenes, e.g. (4.80) which are chromones occurring in garden plants. Even in low concentrations, they produce precocious moulting to give a sterile adult (Bowers etal., 1976). Their site of action is the gland that synthesizes juvenile hormone, which activates the precocene, apparently by epoxidation, and is destroyed by the product. (Brooks, Pratt and Jennings, 1979). [Pg.169]


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See also in sourсe #XX -- [ Pg.542 , Pg.543 ]




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