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Growth Hormone Antagonist Pegvisomant

Pegvisomant (Somavert) Pfizer (2002) Human growth hormone antagonist 4-5 PEGofSkDa Acromegaly... [Pg.49]

Pegvisomant is a growth hormone receptor antagonist registered for the treatment of patients with acromegaly who had insufficient benefit from surgery or radiation. [Pg.389]

Growth hormone requires mediation by somatomedins for many of its actions. These are chiefly formed in the liver, including the important somatomedin C (= insulin-like growth factor 1, IGF-1). Pegvisomant is a newly developed antagonist at the GH receptor and inhibits the production of IGF-1. [Pg.238]

Trainer PJ, Drake WM, Katznelson L, et al. Treatment of acromegaly with the growth hormone-receptor antagonist Pegvisomant. N Engl J Med 2000 342 1171-1177. [Pg.1422]

Van Der Lely AJ, Hutson R, Trainer PJ, et al. Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist. Lancet 2001 358 1754-1759. [Pg.1422]

N. Doyle, M.J. Waters et al. (2001). Binding and functional studies with the growth hormone receptor antagonist, B2036-PEG (pegvisomant), reveal effects of pegylation and evidence that it binds to a receptor dimer. J. Clin. Endocrinol. Metab. 86, 1716-1723. [Pg.371]

Goldenberg N, Racine MS, Thomas P, Degnan B, Chandler W, Barkan A. Treatment of pituitary gigantism with the growth hormone receptor antagonist pegvisomant. J Clin Endocrinol Metab 2008 93 2953-6. [Pg.918]

See other pages where Growth Hormone Antagonist Pegvisomant is mentioned: [Pg.679]    [Pg.451]    [Pg.679]    [Pg.451]    [Pg.708]    [Pg.519]    [Pg.520]    [Pg.520]    [Pg.855]    [Pg.855]    [Pg.97]    [Pg.1404]    [Pg.97]    [Pg.846]   
See also in sourсe #XX -- [ Pg.384 , Pg.394 , Pg.395 , Pg.400 ]



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