Hormone receptor antagonist, melanin

Schaus and Goss reported an enantioselective synthesis of SNAP-7941 62, a potent melanin-concentrating hormone receptor antagonist, by using a chiral phosphoric acid-catalyzed Biginelli reaction (Scheme 9.23) [72]. 

Diaryl-octahydro-pyra/ino[2,1 -c 1,4]thiazines are useful as melanine concentrating hormone receptor ligands <2002W02002/094799>. Pyrazino[2,l-f][l,4]oxazines 245 (Y = 0) and pyrazino[2,1 -c][ 1,4]thiazines 245 (Y = S) exert a tachykinin antagonistic effect <2002W0055518>. 

Melanin concentrating hormone Amgen, Inc. [11] receptor antagonist... 

Muchmore, S. W., Souers, A. J., Akritopoulou-Zanze, I. (2006) The use of three-dimensional shape and electrostatic similarity searching in the identification of a melanin-concentrating hormone receptor 1 antagonist. Chem Biol Drug Des 67, 174-176. 

D., Spar, B., Kowalski, T. Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg. Med. Chem. Lett. 2006, 76(14), 3674-3678. 

Wu, W. L., Burnett, D. A., Spring, R., Qiang, L., Sasikumar, T. K., Domalski, M. S., Greenlee, W. J., O Neill, K., Hawes, B. E. Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists. Bioorg. Med. Chem. Lett. 2006, 76(14), 3668-3673. 

Melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity 06JMC4017. 

J. DeLeon, R. Heurich, H. Lichtblau, Z. Shaposhnik, I. Daniewska, T. R Blackburn, T. A. Branchek, C. Gerald, P. J. Vaysse,C. Forray, Aaf. Med. 2002,8,825-830. Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. 

Sasmal S, Balaji G, Kanna Reddy HR, Balasubrahmanyam D, Srinivas G, Kyasa S, Sasmal PK, Khanna I, Talwar R, Suresh J, Jadhav VP, Muzeeb S, Shashikumar D, Harinder Reddy K, Sebastian VJ, Frimurer TM, Rist 0, Elster L, Hogberg T (2012) Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHRl) antagonists. Bioorg Med Chem Lett 22 3157-3162... 

Johansson, A. (2011). Recent progress in the discovery of melanin-concentrating hormone 1-receptor antagonists. Expert Opinion on Therapeutic Patents, 21, 905-925. 

H.J., Wong, M Norman, D., Lockey P.M., and Roach, A.G. (2004) A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor. Journal of Medicinal Chemistry, 47 (16), 3962-3971. 

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