Hopelessness

As in previous sections, the zeros of l (x, t) in the complex t plane at fixed x are of interest. This appears a hopeless task, but the situation is not that bleak. Thus, let us consider a wavepacket initially localized in the ground state in the sense that in Eq. (50), for some given x. 

Erythromycins. Erythromycin A (14, R = OH, R = CH3, R" = H), the most widely used macroHde antibiotic, was the principal product found in culture broths of Streptomjces eTythreus (39), now reclassified as Saccharopoljspora eythraea (40). It contains a highly substituted aglycone, erythronoHde A, (16, R = R = OH) to which desosamine (1, R = OH, R = H) and cladinose (8, R = CH ) are attached (41). The complete stereochemistry of erythromycin A was estabUshed by x-ray analysis of its hydroiodide dihydrate (42) total synthesis of erythromycin A was a landmark achievement (43), a task previously considered hopeless (44). 

For many years, it was thought that the macro solute forms a new phase near the membrane—that of a gel or gel-like layer. The model provided good correlations of experimental data and has been widely used. It does not fit known experimental facts. An explanation that fits the known data well is based on osmotic pressure. The van t Hoff equation [Eq. (22-75)] is hopelessly inadequate to predict the osmotic pressure of a macromolecular solution. Using the empirical expression... 

The foregoing design questions are highly combinatorial so any exhaustive enumeration tedmique would be hopelessly complicated. A hit-and-miss or trial-and-error approach to conjecturing the solution is likely to fail because it cannot consider the overwhelming number of decisions to be made. Hence, the designer... 

Anssicht,/. outlook, view, prospect, chance. — in Qehmen, contemplate. atissichta los, a. hopeless. reich, a. promising. 

Although government officials attempted to educate the public and military personnel about atomic civil defense, in retrospect these efforts seem hopelessly naive if not intentionally misleading. Army training films advised soldiers to keep their mouths closed while obser"ving atomic test blasts in order to not inhale radioactive flying dirt. Civil defense films used a friendly animated turtle to teach schoolchildren to duck and cover during a nuclear attack—that is, duck under their desks and cover their heads. Such measures, of course, would have offered pitiful protection to those in the blast zone. 

The matter can be subjected to experimental test if Equation 10-5 can be made more tractable. This equation, though generally applicable, is hopelessly cumbersome when 6 is large, as it will always be in actual cases. Fortunately, as 6 becomes very large, Equation 10-5 simplifies to... 

I feel that the future is hopeless and that things cannot improve. 

Full therapeutic effect of the antidepressant may not be attained for 10 days to 4 weeks. Patients with suicidal tendencies must be monitored closely. Report any expressions of guilt, hopelessness helplessness insomnia, weight toss and direct or indirect threats of suicide. 

Many real reaction systems are not amenable to normal mathematical treatments that give algebraic expressions for concentration versus time, but by no means is the situation hopeless. Such systems need not be avoided. The numerical methods presented... 

A drying oven looked hopeless after the fire, at least on the out-... 

The Penicillin Committee became the nucleus of research and production of penicillin, and the efforts of many laboratories, including those of Morin-aga Confectionery, Banyu Pharmaceutical, and the Yamagata Union of Food Companies, brought penicillin into practical use in Japan, especially in the military, by the end of 1944, and many hopeless septicemia patients were... 

Depression occurring as part of bipolar disorder may be severe and accompanied by ideas of guilt and hopelessness, an inability to function at work because of poor concentration and psychomotor retardation or agitation, poor judgement and suicidal ideation. The lifelong risk of suicide in people with this condition is as high as 15%. Factors associated with suicide risk include alcohol misuse, marital separation or divorce, living alone and unemployment, and these are all common secondary consequences of the illness. 

Cognitive deficits Poor concentration Feeling of hopelessness ... 

A generalized kinetic treatment of the array of processes occurring in condensation polymerization might appear hopelessly complex. In the polyesterification of a hydroxy acid, for example, the first step is intermolecular esterification between two monomers, with the production of a dimer... 

The beginner should not be disappointed if at first these operations produce a hopeless mess with practice the facility is gained. 

For amide hydrolysis in base, the initial adduct would revert to starting materials (without remarkable stabilization, an amide ion is a hopeless leaving group, so that path b does not compete with path a), bnt a not very difflcnlt proton transfer gives an intermediate in which the amine is the better leaving gronp and path b can compete with path a. ... 

For amide hydrolysis in acid, proton transfer to give a cationic intermediate is easy, and breakdown to products is favored over reversion to starting material process b is hopelessly bad, but process b is better than a. 

---