Homocysteate

R3Sn(IV)]4H2TPPS, (R = Me, Bu, Ph), respectively, in the solid state, are maintained in solution. Pentacoordination, in a Tbp configuration, eq-Rs, has been proposed for RsSnflV) derivatives of L-homocysteic acid on the basis of IR and Mossbauer spectroscopy The SO3 and NH3 groups of L-homocysteic acid are not involved in the coordination. [Pg.407]

Glutamic acid and its salts (especially the sodium salt) enhance the flavour of many convenience foods. Bejaars et al. (1996) described the determination of free glutamic acid in soups, meat products and Chinese food. The method involves hot water extraction of test portions followed by filtration and dilution. The extracts were treated with N,N-dimethyl-2-mercapto-ethyl-ammonium chloride and o-phtaldialdehyde to convert glutamic acid into a stable fluorescent, l-alkylthio-2-alkyhsoindole. Homocysteic acid was used as the internal standard. Separation was made on a Ci8 column, eluted with... [Pg.117]

Homocyst(e)ine CBS deficiency Cobalamin defects/defi-ciency MTHFR deficiency Methionine adenosyltrans-ferase deficiency Hyperhomocysteinemia Sulfite oxidase deficiency... [Pg.85]

Other neurotransmitters. The abundant glutamate, GABA, and glycine are major neurotransmitters. Do other amino acids also function in the brain Roles for L-aspartate and D-serine (p. 1785) have been identified, but it is very difficult either to discover or to disprove a neurotransmitter function for other amino acids. It is even more difficult for small amounts of various amines and small peptides that are present in the brain. Taurine (Fig. 24-25) is one of the most abundant free amino acids in animals and meets several criteria for consideration as both an inhibitory and an excitatory transmitter.797 798 However, its function is still uncertain (see Chapter 24). Homocysteic acid, formed by oxidation of homocysteine, is a powerful neuroexcitatory substance, but its concentration in the brain is very low.149 d-Aspartate is also present... [Pg.1793]

Actually the irradiation chemistry of even simple amino acids and peptides is much more complex than these equations imply, and many other radiochemical products have been reported (13, 14, 49). These include glyoxylic acid, formaldehyde, hydrogen peroxide, carbon dioxide, succinic acid, aspartic acid, diaminosuccinic acid, methylamine, methane, dimethyl mercaptan, a-aminobutyric acid, methionine sulfoxide, methinonine sul-fone, methionine sulfoxime, homocysteic acid, and several unidentified nitrogen compounds (46, 51). [Pg.44]

James GK, Jones MW, Pudek MR. Homocyst(e)ine levels in patients on phenytoin therapy. Clin Biochem 1997 30(8) 647-649. [Pg.182]

Genest JJ Jr, et al. Plasma homocyst(e)ine levels in men with premature coronary artery disease. J Am Coll Cardiol 1990 ... [Pg.182]

Upchurch GRJr, etal, Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem I 997 272(27) 17012-17017. [Pg.183]

Oxidized to Homocysteine sulphinic acid Homocysteic acid (Glutamic acid analogues) NMDA-Glu-R agonists excitotoxins]... [Pg.111]

Homocysteine or its metabolite homocysteic acid may have a direct neurotoxic effect in the developing neural tube both bind to the Ai-methyl-D-aspartate subtype of glutamate receptor. [Pg.311]

Garg R, MalinowM, Pettinger M, Upson B, and Hunninghake D (1999) Niacin treatment increases plasma homocyst(e)ine levels. American Heart Journal 138, 1082-7. [Pg.425]

Sulfoxides are deoxygenated by BI3 NEt2Ph [23], Sulfides are also cleaved by BI3. Methionine reacts to yield a complex mixture of C-S bond-cleavage products, including homocysteic acid, homoserine, and homoserine lactone [24],... [Pg.93]

C4H9N05S DL-homocysteic acid 504-33-6 25.00 1.3624 2 4013 C4H11N03 tris(hydroxymethyl)methylamine 77-86-1 25.00 1.0382 2... [Pg.215]

M. R. Malinow, Homocyst(e)ine and Arterial Occlusive Diseases, Journal of Internal Medicine 236 (1994) 603-617. [Pg.151]

Badner NH, Spence JD. Homocyst(e)ine, nitrous oxide and atherosclerosis. Balliere s Best Pract Res Clin Anesthesiol 2001 15 185-93. [Pg.2552]

In vertebrates the endogenous ligands may be glutamate, aspartate and possibly homocysteate, and the receptors are found largely in the CNS. On the basis of studies with agonists and antagonists, three main subtypes of these excitatory receptors can be distinguished. [Pg.134]

Figure 16.9. Calibration curve based on determinations of HCY standards. [Reprinted, with permission, from Mohammed T. Shipchandler, and Ewin G. Moore, Clinical Chem. 41 7, 1995, 991-994. Rapid, Fully Automated Measurement of Plasma Homocyst(e)ine with the Abbot Imx Analyzer . Amer. Assos. for Clinical Chemistry.]...

Malinow MR, Bostom AG, Krauss RM. Homocyst(e)ine, diet, and cardiovascular diseases a statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 1999 99 178-82. [Pg.974]

Ray JG, Laskin CA. Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss a systematic review. Placenta 1999 20 519-29. [Pg.977]

Shipchandler MT, Moore EG. Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer. Clin Chem 1995 41 991-4. ... [Pg.979]

Ubbink JB. Assay methods for the measurement of total homocyst(e)ine in plasma. Semin Thromb Hemost 2000 26 233-41. [Pg.980]

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