HiTOPS

D. HiTOPS System by Affymax Research Institute Polyfiltronics/Whatman... 

FIGURE 13.15 HiTOPS System synthesis device (left) and cleavage device (right). 

The Affymax Research Institute has developed an original approach for the synthesis of organic compounds in 96 deep well plates. The high-throughput organic parallel synthesis (HiTOPS) systemP l (Figure 4) utilizes a variety of 96 deep well filtration microtiter plates available from Whatman Polyfiltronics. 

One of the advantages of this method is the commercial availability of the above devices. The HiTOPS device has been used in the synthesis of combinatorial libraries of piper-azinedionesl l for the development of highly selective inhibitors of collagenase-1. 

Figure 15 HiTOPS System Synthesis Device (left) and Cleavage Device (right).

Polyfiltronics/Whatman, which manufactures, distributes, and supports the HiTOPS System in the United States, Europe, and Japan. 

The HiTOPS device was recently used in the synthesis of combinatorial libraries of dike-topiperazines [61] for the development of highly selective inhibitors of collagenase-1. The HiTOPS system is easy to use, has an ergonomic design, and allows the use of up to 50 mg of a resin per well. The other advantage of this method is the commercial availability of the described devices. Affymax has licensed its technology to Whatman/Polyfiltronics, which manufactures the HiTOPS System. 

The most ergonomic design of a 96-well based device for parallel synthesis of organic compounds was introduced by Affymax Research Institute their HiTOPS system is described in section 3.4.3.1 of this chapter. 

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