Hitchings, George

Berkeley, George. Siris a chain of philosophical reflexions and inquiries concerning the virtues of tar water, and divers other subjects connected together and arising one from another. / By the Right Rev. Dr. George Berkeley, Lord Bishop of Cloyne, and author of The minute philosopher [1 line of biblical quotation and 1 line of Horace in Latin], The second edition, / improved and corrected by the author ed. [London] Dublin printed, London re- printed, for W. Innys, and C. Hitch,... and C. Davis..., 1754. [3], 4-174, [2] p. 

The authors wish to express their appreciation to Dr. William B. House and Dr. George H. Hitchings for their encouragement, to Dr. Eugene G. Podrebarac for many helpful discussions, and Miss Renee Laube for assistance in the literature search, and to Miss Soula Culver for typing this manuscript. 

American chemist Gertrude B. Elion (right) with her colleague George H. Hitchings, recipients, with Sir James W. Black, of the 1988 Nobel Prize in physiology or medicine, for their discoveries of important principles for drug treatment. ... 

Wellcome Pharmaceutical Laboratories, George Hitchings, it recognized the work of this pair that led to the development of a series of important drugs, among these drugs used to treat malaria, the leukemias, viral infections, and some forms of impaired immune response. 

Diamino-5-(/>-chlorophenyl)- George Hitchings (USA, sensitive than human)... 

Gertrude Elion, George Hitchings, and James Black... 

During World War II, chemists at ICI, then a newcomer in pharmaceutical research, discovered antimalarials based on biguanidines, including proguanil (89) (Paludrine, 1944), prepared from 3-chloroaniline (Scheme 28), and its metabolite dihydrodiazine (90). In 1950, George Hitchings developed the diaminotriazine into what became known as pyrimethamine (Diaprim) (91) (Scheme 29)98. 

Antimetabolites in cancer treatment was discovered by George Hitchings (1905-1998) and Gertrude Elion... 

Mercaptopurine (MP Fig. 14-21) is one of many drugs discovered by the Nobel Lameates Gertrude Elion and George Hitchings. MP was first synthesized in the early 1950s and remains a very useful anticancer dmg. Like 5-fluorouracil, MP has several mechanisms of toxicity that vary from one cell type to another. MP enters cells and is metabolized in the following way ... 

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