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Hitchings

Wellcome Research Laboratories, Research Triangle Park, N. C. [Pg.1]

Fourth Award in Medicinal Chemistry, Thirteenth National Medicinal Chemistry Symposium of the American Chemical Society, Iowa City, Iowa, June 18-22, 1972 [Pg.1]

The exploration of enzymes and metabolic pathways by means of antimetabolites has been productive of both new medicinal agents and advances in fundamental knowledge.  [Pg.1]

This essay will attempt to describe the method of working primarily througih one example, selective inhibitors of the biogenesis and utilization of folates and their application to anti-microbial chemotherapy. Specifically, the combination of trimethoprim and sulfamethoxazole is now available in some 60 countries of the world (with the notable exception of the United States) and has been used in some 25 x 10 courses of therapy with highly satisfactory results .  [Pg.1]

Its origins can be traced to early findings of the present program, to the detection of antimetabolites that possess selective effects, Substances were found that exhibited a consistent pattern of antlmetabollc [Pg.1]


Gilman [124] and Westwood and Hitch [135] have applied the cleavage technique to a variety of crystals. The salts studied (with cleavage plane and best surface tension value in parentheses) were LiF (100, 340), MgO (100, 1200), CaFa (111, 450), BaFj (111, 280), CaCOa (001, 230), Si (111, 1240), Zn (0001, 105), Fe (3% Si) (100, about 1360), and NaCl (100, 110). Both authors note that their values are in much better agreement with a very simple estimate of surface energy by Bom and Stem in 1919, which used only Coulomb terms and a hard-sphere repulsion. In more recent work, however, Becher and Freiman [126] have reported distinctly higher values of y, the critical fracture energy. ... [Pg.279]

Westwood and Hitch suggest, incidentally, that the cleavage experiment, not being fully reversible, may give only a bond-breaking or nearest-neighbor type of surface energy with little contribution from surface distortion. [Pg.280]

G. H. Hitchings, ed. Inhibition of Eolate Metabolism in Chemotherapy. The Origins and Uses of Co-trimoxa le, Springer-Vedag, Berlin, 1983. [Pg.470]

RM Consultants Ltd, Suite 7, Hitching Court Abingdon, Oxon, 0X14 IDY, ENGLAND Phone 0235 - 555755... [Pg.40]

Thioxo-3-oxo-2,3,4,5-tetrahydro-l,2,4-triazine (4-thio-6-azauracil) (88) and 3,5-dithioxo-2,3,4,5-tetrahydro-l,2,4-triazine (2,4-dithio-6-azauracil) (89) w ere prepared by Hitchings et al. treating 6-aza-... [Pg.222]

D2 G. H. Hitchings, Drugs, Parasites Hosts, Symp. Middlesex Hasp. Med. School p. 196 (1962). [Pg.184]

G. H. Hitchings and his co-workers have made a comprehensive studyof antifolic acid activity in 2,4-diaminopyrimidines. They have demonstrated that very many such compounds, both simple and fused, show such activity. In the course ofthis work some pyrido[3,2-d]-pyrimidines and a large number of pyrido[2,3-d]pyrimidinesi ... [Pg.198]


See other pages where Hitchings is mentioned: [Pg.291]    [Pg.336]    [Pg.322]    [Pg.496]    [Pg.510]    [Pg.44]    [Pg.225]    [Pg.229]    [Pg.235]    [Pg.235]    [Pg.200]    [Pg.570]    [Pg.934]    [Pg.644]    [Pg.539]    [Pg.208]    [Pg.221]    [Pg.274]    [Pg.306]    [Pg.401]    [Pg.448]    [Pg.150]    [Pg.152]    [Pg.161]    [Pg.161]    [Pg.162]    [Pg.162]    [Pg.165]    [Pg.165]    [Pg.184]    [Pg.190]    [Pg.191]    [Pg.191]    [Pg.334]    [Pg.406]    [Pg.406]    [Pg.407]    [Pg.415]    [Pg.421]    [Pg.421]    [Pg.422]    [Pg.435]    [Pg.284]    [Pg.282]   
See also in sourсe #XX -- [ Pg.377 ]




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