SEARCH Articles Figures Tables Affinity-Based Screening Methodologies and Their Application in the Hit-to-Lead Phase Chemoinformatic Tools for Library Design and the Hit-to-Lead Process A Users Perspective Early Optimization or Hit-to-Lead Libraries Filtering hits to leads Hit to Lead also Known as Closed Loop Hit to lead program Hit, hits Hit-to-lead optimization Hit-to-lead phase Hit-to-lead process Hit-to-lead stage Hit-to-lead strategies The Hit-to-lead Process Visualization of Library Designs during Hit-to-lead Efforts