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Hit-to-lead stage

A number of criteria are essential for the decision to take up a hit compound singleton or compound series to the hit-to-lead stage. The criteria. [Pg.21]

In the hit-to-lead stage of drug discovery, compounds are generally only available in solvents such as DMSO for a number of reasons ... [Pg.105]

Figure 11.7 LFA-1 antagonist refinement. Active compounds obtained during the hit expansion and hit-to-lead stages are shown. Figure 11.7 LFA-1 antagonist refinement. Active compounds obtained during the hit expansion and hit-to-lead stages are shown.
Spalding DJ, Marker AJ, Bayliss MK. Combining high-throughput pharmacokinetic screens at the hits-to-leads stage of drug discovery. Drug Discov Today 2000 5(12 Suppl l) 70-76. [Pg.194]

TABLE 14.1 The Stage-Appropriate Analysis Model Applied for Hit-to-Lead and Lead... [Pg.405]

See other pages where Hit-to-lead stage is mentioned: [Pg.134]    [Pg.345]    [Pg.536]    [Pg.103]    [Pg.104]    [Pg.163]    [Pg.404]    [Pg.419]    [Pg.255]    [Pg.24]    [Pg.25]    [Pg.81]    [Pg.134]    [Pg.345]    [Pg.536]    [Pg.103]    [Pg.104]    [Pg.163]    [Pg.404]    [Pg.419]    [Pg.255]    [Pg.24]    [Pg.25]    [Pg.81]    [Pg.450]    [Pg.19]    [Pg.19]    [Pg.20]    [Pg.20]    [Pg.60]    [Pg.127]    [Pg.225]    [Pg.170]    [Pg.310]    [Pg.397]    [Pg.157]    [Pg.22]    [Pg.93]    [Pg.166]    [Pg.187]    [Pg.305]    [Pg.226]    [Pg.280]    [Pg.161]    [Pg.282]    [Pg.177]    [Pg.337]    [Pg.4013]    [Pg.292]    [Pg.727]    [Pg.234]    [Pg.492]    [Pg.5]    [Pg.100]    [Pg.299]    [Pg.217]   
See also in sourсe #XX -- [ Pg.105 , Pg.428 ]



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