Histone deacetylases identification

Seigneurin-Berny, D., Verdel, A., CuRTET, S., Lemercier, C., Garin, J., Rousseaux, S., and Rhochbin, S., Identification of components of the murine histone deacetylase 6 complex link between acetylation and... 

Zhou X, Richon VM, Rifkind RA, Marks PA (2000) Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5. Proc Natl Acad Sci USA 97(3) 1056-1061 Zhou X, Marks PA, Rifkind RA, Richon VM (2001) Cloning and characterization of a histone deacetylase, HDAC9. Proc Natl Acad Sci U S A 98(19) 10572-10577 Zoghbi HY, Orr HT (2000) Glutamine repeats and neurodegeneration. Annu Rev Neurosci 23 217-247... 

Gray SG, Ekstrom TJ (2001) The human histone deacetylase family. Exp Cell Res 262 75—83 Greiner D, Bonaldi T, Eskeland R, Roemer E, Imhof A (2005) Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem BioH 143-145 Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem 276(42) 38837-38843... 

Joseph J, Mudduluru G, Antony S, Vashistha S, Ajitkumar P, Somasundaram K (2004) Expression profiling of sodium butyrate (NaB)-treated cells Identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB. Oncogene 23 6304—6315 Kao H-Y, Lee C-H, Komarov A (2002) Isolation and characterization of mammalian HDACIO A novel histone deacetylase. J Biol Chem 277 187-193... 

Scarpelli R et al (2008) Studies of the metabolic stability in cells of 5-(trifluoroacetyl) thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors. Bioorg Med Chem Lett 18(23) 6078-6082... 

Ontoria JM et al (2009) Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy. J Med Chem 52(21) 6782-6789... 

Essentially the functional counterpart of coactivators, corepressor proteins bind to many NRs in the absence of ligand and serve to repress basal transcriptive activity [62], Corepressors play a particularly important role for NRs that are found almost exclusively in the nucleus, unlike the apo steroid receptors that are cytoplasmically localized. Studies involving the nuclear-localized receptors TR and RAR led to the identification of silencing mediator of retinoid and thyroid (SMRT) receptors and nuclear receptor corepressor (NCoR) [63, 64]. Both SMRT and NCoR recruit histone deacetylases (HDACs), namely, HDAC3, which function to reverse the chromatin unwinding result of the coactivator-recruited histone acetylases [65],... 

Jackson MD, Denu JM. Structural identification of 2 - and 3 -0-aceiyl-ADP-ribose as novel metabolites derived from the Sir2 family of -NAD-f-dependent histone/protein deacetylases. J Biol Chem 2002 277 18535-18544. 

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