Histological activity index

The histological components of chronic hepatitis can be evaluated semiquantitatively and summarized in a histological activity index (HAI). This index combines the values for the inflammatory infiltrate, liver cell necrosis... 

Goldstein NS, Blue DE, Hankin R, et al. Serum alpha-fetoprotein levels in patients with chronic hepatitis C. Relationships with serum alanine aminotransferase values, histologic activity index, and hepatocyte MIB-1 scores. AmJ Clin Pathol. 1999 111 811-816. 

Pellets were removed and prepared for histological examination as previously described (37). An arbitrary "induction index", defined as the mean fractional area represented by induced cartilage, (IC) and induced bone (IB), was used to characterize the elicitation of osteoblastic activity by the DBP. A summary of the results of these experiments is presented in Table II. At 6 and 17 weeks following implantation of the DBP significant bone formation is observed in the C rats. No cartilage was apparent in the 2 week specimens from the L rats. At 6 and 17 weeks some induced bone was present. At no time throughout the course of experiments did the DBP elicit formation of either cartilage or bone in the Hn-deplete rats. 

---