Histidinol

This enzyme [EC 1.1.1.23] catalyzes the reaction of l-histidinol with two NAD+ to produce L-histidine and two NADH. L-Histidinal will also serve as a substrate for this protein. The Neurospora crassa enzyme will also catalyze the reactions of phosphoribosyl-AMP cyclohydrolase [EC 3.5.4.19] and phosphoribosyl-ATP pyrophosphatase [EC 3.6.1.31]. 

This pyridoxal-phosphate-dependent enzyme [EC 2.6.1.9], also called imidazolylacetolphosphate aminotransferase and imidazole acetolphosphate transaminase, catalyzes the reversible reaction of histidinol phosphate with a-ketoglutarate (or, 2-oxoglutarate) to produce 3-(imidazol-4-yl)-2-oxopropyl phosphate and glutamate. 

This enzyme [EC 3.1.3.15] catalyzes the hydrolysis of histidinol phosphate to generate histidinol and orthophosphate. 

This enzyme [EC 3.5.4.19] catalyzes the hydrolysis of 5-phosphoribosyl-AMP to produce 5-(5-phospho-D-ribo-sylaminoformimino)-l-(5-phosphoribosyl)tmidazole-4-carboxamide. The enzyme isolated from Neurospora crassa can also catalyze the reactions of histidinol dehydrogenase and phosphoribosyl-ATP pyrophosphatase. 

HISTAMINE N-METHYLTRANSFERASE HISTIDINE AMMONIA-LYASE DEHYDROALANINE HISTIDINE DECARBOXYLASE Histidine decarboxylase reduction, BOROHYDRIDE REDUCTION HISTIDINOL DEHYDROGENASE... 

HISTIDINOL-PHOSPHATE PHOSPHATASE HISTIDYL-tRNA SYNTHETASE HISTONE KINASE Hofmann rule,... 

GLYOXYLATE REDUCTASE HISTIDINOL DEHYDROGENASE HOMOISOCITRATE DEHYDROGENASE HOMOSERINE DEHYDROGENASE HYDROGEN DEHYDROGENASE... 

GLYCOGEN PHOSPHORYLASE HISTIDINOL-PHOSPHATE PHOSPHATASE myo-INOSITOL 1-MONOPHOSPHATASE... 

In very pure nonpolar dielectric liquids, electron injection currents at very sharp tips follow the Fowler-Nordheim voltage dependence (Halpem and Gomer, 1969), just as is the case in solid insulators, and in a gas, as described before. In a study of the electrochemical behavior of CNT cathodes (Krivenko et al., 2007) direct experimental proof was found of electron emission into the liquid hexamethylphosphortriamide, which was chosen because it is a convenient solvent for the visualization of solvated electrons at room temperature the solution will show an intense blue coloration upon the presence of solvated electrons. Electron spin resonance showed prove of a free electron. Electrogenerated (as opposed to photogenerated) solvated electrons have been used in the synthesis of L-histidinol (Beltra et al., 2005), albeit that in that work the electrons were generated electrochemically from a solution of LiCl in EtNH2, which is a solvent that is easier to handle than liquid ammonia (boiling points at atmospheric pressure are 17 °C and -33.34 °C, respectively). 

The biosynthesis of pilocarpine in Pilocarpus pennatifolius was studied by the administration of radiolabeled precursors. Radioactive sodium acetate, histidine, histidinol, methionine, and threonine were administered by the cut-stem method. Histidine, methionine, and threonine were administered together by a wick inserted through the stem of an intact plant. Sodium acetate and histidine were fed to root cuttings by suspending the roots in aqueous solutions of the precursors. After 64 - 7 5 h, the roots were harvested and total alkaloid extracts made. These extracts were then fed to stem cuttings. 

E. Coli L-histidinol Dehydrogenase Octahedral Zinc Site... 

E. coli L-histidinol dehydrogenase IKAE 1 Gln 2 HiSaa 97 Aspa HiSa free His... 

Hansen BS, Vaughan MH, Wang LJ. 1972. Reversible inhibition by histidinol of protein synthesis in human cells at the activation of histidine. J Biol Chem 247 3854-3857. (Mechanistic study validating the use of amino-alcohols as AA-synthetase inhibitors)... 

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