High throughput reactor

On the reactor side, the gas mixture enters from the top and is separated into 16 individual streams, going to each one of the reactors. Figure 11.3 shows the side view of the high-throughput reactor setup. The reactors are vertical flow-through reactors with a... 

Huybrechts, W., Mijoin, J., Jacobs, P.A. et al. (2003) Development of a fixed-bed continuous-flow high-throughput reactor for long-chain n-alkane hydroconversion. Appl. Catal. A Gen., 243, 1. 

Rahman et al used a novel high throughput reactor to produce substituted acetylene by the Sonogashira reaction and the Mizoroki-Heck reaction in series using the same IL in a one-pot operation. The products were obtained in good yields and the contamination from the previous reaction was not carried forward to the next. 

Jacobs et al. showed in a feasibility study that it is possible to obtain meaningful kinetic data using a high-throughput reactor [36]. Decane hydroisomerization was studied over Pt-loaded ultrastabilized Y type zeolites. Complete analysis of the complex product mixture could be achieved in 3.2 minutes using a multicapillary column, and the kinetic data obtained agreed well with those of a kinetic model derived for a conventional reactor. 

The authors used a 16 channel reactor at a pressure of 25 bar and a temperature of 400°C and studied zeolite catalysts with different ring sizes and pore connectivity. A clear correlation between the dealkylation selectivity for ethylbenzene and the zeolite pore volume was observed. Dealkylation selectivity increased with decreasing pore volume. In addition, toluene, which is formed by a bimolecular reaction as a primary product, is also favoured by specific pore systems, with that of zeolite beta and ITQ-23 being the most favourable ones. This study showed, that the combination of high-throughput reactors with properly designed experiments can accelerate the understanding of the catalytic action, in this case of zeolites. 

Decane hydroisomerization experiments were performed using a high-throughput reactor with 16 parallel reactor tubes [12]. Samples were impregnated with an aqueous [Pt(NH3)4]Cl2 solution to obtain a 0.5 wt.% nobel metal loading and then palletized in size between 125 and 250 pm. 50mg of catalyst was loaded in the reactors and activated in-situ at 400°C for Ih in O2, N2 and H2. A fixed contact time of 1656 kg s/mol was used along with a temperature step of 10°C. The reaction was performed at a total pressure of... 

Accordingly, selection and optimization of catalysts for various gas-liquid reactions can be accelerated for conditions close to the technical process since miniaturized high-throughput reactors with optimal size reveal improved mixing efficiency. Moreover, the critical scale-up parameters can also be derived from this methodology. 

Today parallel reactor systems for rapid catalyst testing under real process conditions are state-of-the-art. An example of an integrated system is the 48-parallel high-throughput reactor, which can be apphed to discover and to optimize new heterogeneous catalysts. It provides continuous flow of the reactants through separate... 

Olefin polymerization in batch reactors is not common. Laboratory-scale high-throughput reactors are perhaps one of the few examples of such reactors applied to olefin polymerization. Some olefin polymerization tubular reactors can also be treated as batch reactors, where a polymerization-time to reactor-length transformation can be made and directly applied to the equations derived above if the tubular reactor has plug-flow residence time. 

Liu W, Wang Y, Wilcox W, Li S. A compact and high throughput reactor of monolithic-structured catalyst bed for conversion of syngas to liquid fuels. AIChE J. 2012 58 2820-2829. 

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