High resolution-magic angle spinning spectroscopy

Cervical cancer tissue characterized by high-resolution magic angle spinning MR spectroscopy, MAGMA), Magn. Re-son. Mater. Phys., Biol. Med. 16, 174-181. 

High-Resolution Magic Angle Spinning and Cross-Polarization Magic Angle Spinning Solid-State NMR Spectroscopy... 

Griffin, J.L. and Corcoran, O., High-resolution magic-angle spinning 13C NMR spectroscopy of cerebral tissue, Magn. Reson. Mater. Phys. Biol. Med., 18,1352, 2005. 

Scheldt, H.A. et al., Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy, Biochim. Biophys. Acta, 1663, 97, 2004. 

A. Bianco, J. Furrer, D. Limal, G. Guichard, K. Elbayed, J. Raya, M. Piotto and J. P. Briand, Multistep synthesis of 2,5-diketopiperazines on different solid supports monitored by high resolution magic angle spinning NMR spectroscopy,./. Comb. Chem., 2000, 2, 681-690. 

N. J. Waters, S. Garrod, R. D. Farrant, J. N. Haselden, S. C. Connor, J. Connelly, J. C. Lindon, E. Holmes and J. K. Nicholson, High-resolution magic angle spinning H-l NMR spectroscopy of intact liver and kidney Optimization of sample preparation procedures and biochemical stability of tissue during spectral acquisition, Anal. Biochem., 2000, 282, 16-23. 

D. Morvan, A. Demidem, J. Papon, M. De Latour and J. C. Madelmont, Melanoma tumors acquire a new phospholipid metabolism phenotype under cystemustine as revealed by high-resolution magic angle spinning proton nuclear magnetic resonance spectroscopy of intact tumor samples, Cancer Res., 2002, 62, 1890-1897. 

Bollard ME, Murray AJ, Clarke K, Nicholson JK, Griffin JL. A smdy of metabolic compartmentation in the rat heart and cardiac mitochondria using high-resolution magic angle spinning IH NMR spectroscopy. FEBS Lett. 2003 553 73-78. 

Griffin JL, Blenkiron C, Valonen PK, Caldas C, Kauppinen RA. High-resolution magic angle spinning IH NMR spectroscopy and reverse transcription-PCR analysis of apoptosis in a rat glioma. Anal. Chem. 2006 78 1546-1552. 

Due to strong line-broadening, standard gel-phase NMR spectroscopy cannot be used for the analysis of protons. High resolution magic angle spinning (HRMAS) NMR spectroscopy has recently been developed to cover this gap.t l This method has the limitation that specialized HRMAS probes are required however, the method has been applied successfully to a variety of solid supports. Amazingly narrow lines are observed for the proton resonances and 2-D versions of HRMAS experiments can be very easily implemented. 

J.-H. Chen S. Singer, High-Resolution Magic Angle Spinning NMR Spectroscopy. In The Handbook of Metabonomics and Metabolomics J. C. Lindon, J. K. Nicholson, E. Holmes, Eds. Elsevier Amsterdam, 2007 pp 113-148. 

High-Resolution Magic Angle Spinning (MAS) NMR Spectroscopy for On-Bead Analysis of Solid-Phase Synthesis... 

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