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High performance liquid chromatography interfacing

HPLC-MS interfaces were developed after GC interfaces and considerably more work was required to produce efficient interfaces capable of dealing with the large vapour volumes from a liquid eluant [8,9]. Possible solutions to the problem include [Pg.379]

Early interfaces used liquid nitrogen or helium cryogenic techniques to remove the solvent vapour, but these were rather cumbersome and not too efficient. Moving belt transport systems were also one of the first interfaces to be developed incorporating a flash vaporiser to remove the solvent before the sample reached the ion source. The main approaches used today are based on thermospray, atmospheric pressure and particle beam interfacing techniques [10]. [Pg.379]


RA Williams, R Macrae, MJ Shepherd. Non-aqueous size-exclusion chromatography coupled online to reversed phase high performance liquid chromatography. Interface development and applications to the analysis of low-molecular weight contaminants andadditives in foods. J Chromatogr 477 315-325, 1989. [Pg.619]

DiNunzio, J. E. Pharmaceutical applications of high-performance liquid chromatography interfaced with Fourier transform infrared spectroscopy. Journal of Chromatography. 626 97-107, 1992. [Pg.358]

TRANSPARENT FLOW GATING INTERFACE WITH PACKED CAPILLARY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-CAPILLARY ZONE ELECTROPHORESIS... [Pg.210]

This is not the case when high performance liquid chromatography (HPLC) and MS are considered where, due to the incompatibilities of the two techniques, they cannot be linked directly and an interface must be used, with its prime purpose being the removal of the chromatographic mobile phase. Unfortunately, no single... [Pg.19]

To understand the principles of operation of each of these interfaces, in particular with regard to the way in which they achieve compatibility between high performance liquid chromatography and mass spectrometry. [Pg.133]

Reversed-phase Cig chromatography column. Keystone Scientific Betasil, 100 x 2.0-mm i.d., 5-pm particle size, 100 A, Part No. 105-701-2-CPF TSQ 7000 LC/MS/MS system with electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI) interface and gradient high-performance liquid chromatography (HPLC) unit, or equivalent Vacuum manifold for use with SPE cartridges (Varian Vac Elut 10 or equivalent)... [Pg.491]

Liu, C. L. and Verma, S. S., Direct coupling of ionic high performance liquid chromatography with electrospray ionization mass spectrometry utilizing a microdialysis junction interface, ]. Chromatogr. A, 835, 93, 1999. [Pg.310]

Takeuchi, T. Watanabe, S. Kondo, R Ishii, D. Goto, M. Improvement of the Interface for Coupling of FAB-MS and Micro High-Performance Liquid Chromatography. J. Chromatogr. 1988, 435, 482-488. [Pg.408]

D Commercial COTS controlled by external computer Hybrid systems such as automated dissolution workstation with high-performance liquid chromatography (HPLC) or ultraviolet-visible (UV-Vis) interface Liquid chromatographs, gas chromatographs, UV/Vis spectrophotometers, Fourier transform infrared (FTIR) spectrophotometers, near-infrared (NIR) spectrophotometers, mass spectrometers, atomic absorption spectrometers, thermal gravimetric analyzers, COTS automation workstations... [Pg.793]

A. High-performance liquid chromatography-mass spectrometry Weidolf and Covey [121] described the application of the ionspray interface for liquid chromatography and atmospheric-pressure ionization mass spectrometry to samples obtained in a study on the metabolism of... [Pg.233]

Diemer, J. and Heumann, K.G. (1997) Bromide/bromate speciation by NTI-IDMS and ICP-MS coupled with ion exchange chromatography. Fresenius J. Anal. Chem., 357,74-79. Duan, YX., Wu, M., Jin, Q.H. and Hieftje, G.M. (1995) Vapour generation of nonmetals coupled to microwave plasma-torch mass-spectrometry. Spectrochim. Acta B, 50,355-368. Ebdon, L., Hill, S. and Jones, R (1987) Interface system for directly coupled high performance liquid chromatography-flame atomic absorption spectrometry for trace metal determination./. Anal. At. Spectrom., 2, 205-210. [Pg.83]

Raynor, M.W., Dawson, G.D., Balcerzak, M., Pretorius, W.G. and Ebdon, L. (1997) Electrospray nebulisation interface for micro-high performance liquid chromatography inductively coupled plasma mass spectrometry. J. Anal. At. Spectrom., 12, 1057-1064. [Pg.87]

Blais, J.-S., Huyghues-Despointes, A., Momplaisir, G.-M. and Marshall, W.D. (1991) High-performance liquid chromatography-atomic absorption spectromety interface for the determination of selenoniocholine and trimethylselenonium cations applications to human urine./. Anal. At. Spectrom., 6, 225-232. [Pg.432]

High, K.A., Azani, R., Fazekas, A.F., Chee, Z.A. and Blais, J.-S. (1992) Thermospray-microatomizer interface for the determination of trace cadmium and cadmium-metallothioneins in biological samples with flow injection- and high-performance liquid chromatography-atomic absorption spectrometry. Anal. Chem., 64, 3197-3201. [Pg.435]


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