High Molecular Weight subunits

Pyle SJ, Amamath V, Graham DG et al. 1993. Decreased levels of the high molecular weight subunit of neurofilaments and accelerated neurofilament transport during the recovery phase of 2,5-hexanedione exposure. Cell Motil Cytoskeleton 26(2) 133-143. 

Mr tetramerk complex. It is composed of (wo identical high molecular weight subunits (Mr 83,000). which are heavily glycosylated and lack enzymatic... 

Wieser, H., Zimmermann, G. 2000. Importance of amounts and properties of high molecular weight subunits of glutenin for wheat quality. Eur Food Res Technol 210 324—330. 

Shewry, P.R., Halford, N.G., Tatham, A.S., Popineau, Y., Lafiandra, D., and Belton, P.S. (2003). The high molecular weight subunits of wheat glutenin and their role in determining wheat processing properties. Adv. Food Sci. Nutrition 45 219-302. 

Parchment, O., Tatham A.S., Shewry, P.R., and Osguthorpe, D.J. (2001). Molecular modelUng of the central repetitive domains of the high molecular weight subunits of wheat. Cereal Chem., 49, 268-275. 

Carboxypeptidase N is synthesized in the liver [103] and circulates as a 280,000 Mr tetrameric complex. It is composed of two identical high molecular weight subunits (Mr 83,000), which are heavily glycosylated and lack enzymatic activity, and two identical low molecular weight subunits (Mr 55,000), which contain the active center [104,105]. 

Payne, P.I., Holt, L.M., and Law, C.N. Structural and genetic studies on the high-molecular-weight subunits of wheat glutenins. Part I. Allelic variation in subunits amongst varieties of wheat (Triticum aestivum). Theor. Appl. Genet. 60 229-236, 1981. 

Payne, P. L, K. G. Corfield, and J. A. Blackman. 1981. Correlation between the inheritance of certain high-molecular-weight subunits of glutenin and bread-making quality in progenies of six crosses of bread wheat. Journal of the Science of Food and Agriculture 32 51-60. 

A. R. Slabas and A. Hellyer, Rapid purification of a high molecular weight subunit polypeptide form of rapeseed acetyl-CoA carboxylase. Plant Sci. 39 177... 

Solid state 13C CPMAS NMR spectra of Wheat High Molecular Weight (W.HMW) subunits show well resolved resonances identical with spectra of dry protein and peptide samples [24], Most of the amino acids side-chain resonances are found in the 0-35 ppm region followed by the alpha resonances of the most abundant amino acids glycine, glutamine and proline at chemical shifts of 42, 52 and 60 ppm, respectively, and the carbonyl carbons show a broad peak in 172-177 ppm region. The CPMAS spectra of hydrated whole HMW provides important information on the structural characteristics. 

High-molecular-weight complex peptidases composed of a series of low-molecular-weight subunits are found in the cytosol [27], These enzymes were... 

Dewar, D. H., Amato, M., Ellis, H. J., Pollock, E. L., Gonzalez-Cinca, N., Wieser, H., and Ciclitira, P. J. (2006). The toxicity of high molecular weight glutenin subunits of wheat to patients with coeliac disease. Eur. ]. Gastroenterol. Hepatol. 18, 483-491. 

The cyclosome (or APC) is a high molecular weight complex that degrades proteins containing a specific recognition sequence, the destruction box (see chapter 13.2.4). Substrates are cell cycle regulators as e.g. cyclins, kinase inhibitors and spindle-associated proteins. Importantly, some forms of the cyclosome require phosphorylation in order to be active (fig. 2.15B). It is still unclear which of the many subunits carries the E3 enzyme activity. 

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