Hesperetin-7-rutinoside

Synonyms (2S)-7-[[6-0-(6-Deoxy-a-L-mannopyranosyl)-P-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-l-benzopyran-4-one hesperitin 7-rhamnoglucoside hesperetin-7-rutinoside. 

Figure 6.1. Flavonoids shown to be of nutritional significance are, for the most part, derivatives of either flavone or flavanone, e.g. quercetin (3,3,4,5,7-pentahydroxyflavone), rutin (quercetin-3-rutinoside), naringenin (4,5,7-trihydroxy flavanone), hesperetin (3,5,7-tri-hydroxy-4-methoxyflavanone) and hesperidin (hesperetin-7-rutinoside)...

Hesperidin hesperetin 7-rutinoside, a Flavanone (see) glycoside which makes up 8 % of the dry weight of orange peel. 

Hesperidin [520-26-3] (hesperetin(7-rhamnoglucoside or 7-rutinoside)) (57) contains a core structure of phloroglucinol. A relative of this series i troxerutin [7085-55 t]y which is a component of Paroven (58) and is used in the treatment of venous problems. 

C12H22O10. Mr 326.30. Highly hygroscopic powder, mp. 189-192 C (decomp.), (aJi> +3.2 -0.8" (HjO). Hydrolysis of the disaccharide with dilute HCI furnishes I mol. L- L-rhamnose and 1 mol. D- glucose. R. occurs in rutin and hesperidin (see hesperetin) in glycosidically bound form (as rutinoside) other an-thocyanidin rutinosides are responsible for the black color of black currants. 

Hesperetin 7-rhamnoglucoside Hesperidoside Hesperitin-7-rhamnoglucoside, Hesperitin-7-rutinoside Vitamin P... 

Hesperetin shows cytotoxic effects, at concentrations of 40 and 80 pM, through caspase 3 activation in HL-60 cells and is more cytotoxic than hesperidin. The rutinoside group present at C-7 of hesperidin attenuates the apoptotic cell death in HL-60 cells [52], Naringenin induces apoptosis of KATOIII and MKN-7 gastric cancer cells and HepG2,... 

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