Hesperetin-rhamnoglucoside

Hesperidin [520-26-3] (hesperetin(7-rhamnoglucoside or 7-rutinoside)) (57) contains a core structure of phloroglucinol. A relative of this series i troxerutin [7085-55 t]y which is a component of Paroven (58) and is used in the treatment of venous problems. 

Synonyms (2S)-7-[[6-0-(6-Deoxy-a-L-mannopyranosyl)-P-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-l-benzopyran-4-one hesperitin 7-rhamnoglucoside hesperetin-7-rutinoside. 

Herox 0200HA, 0200MA, 0200SA. See Nylon Hesperetin, 7-(6-0-(6-deoxy-a-L-mannopyranosyl)-P-D-glucopyranoside Hesperetin 7-rhamnoglucoside. See Hesperidin Hesperidin... 

Hesperetin 7-rhamnoglucoside Hesperidoside Hesperitin-7-rhamnoglucoside, Hesperitin-7-rutinoside Vitamin P... 

Hesperidin derivatives have been shown to act as inhibitors of hyaluronidase (Beiler and Martin 1947,1948) and, as a rather remarkable application of this property, hesperidin solubilized by phosphorylation has been shown to suppress fertility (Sieve, 1952). It is suggested that the phosphorylated hesperidin, which can be administered orally, produces its effect by inhibiting the liquefaction of a hyaluronic acid gel which is necessary before the spermatozoon can penetrate the ovum. Since the results vary with different preparations, Martin (1953) suggests that the effect is due to one particular component of a complex mixture of phosphorylated derivatives. Insofar as both the aglycone hesperetin and its 7-rhamnoglucoside hesperidin, unless phosphorylated, are extremely insoluble, it is unlikely that any such action can be expected of the flavanones themselves when present in foodstuffs. 

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