Hepatoprotective agent

Jasawant, B., Ragunathan, V., and Sulochana, N., A rare flavonol glycoside from Aerva tomentosa Forsk as antimicrobial and hepatoprotective agent, Indian J. Chem., 42B, 956, 2003. 

The roles that flavonoids play as anticancer, radical-scavenging, antiinflammatory and hepatoprotective agents have also been documented... 

Polyphenolic extract of fenugreek seed acts as a protective agent against ethanol-induced abnormalities in the liver and the effects are comparable with those of a known hepatoprotective agent, silymarin (Kaviarasan and Anuradha, 2007). 

Crocenzi PA, Roma MG (2006) Silymarin as a New Hepatoprotective Agent in Experimental Cholestasis New Possibilities from an Ancient Medication. Curr Med Chem 13 1055... 

As shown in equation 2, the lithium enolate oxidation with O2, followed by sodium sulphite reduction, has been applied with success to oxidation of the enolate derived from 1 the nature of the reducing agent has been decisive for the direct preparation of the hepatoprotective agent Clausenamide (2). As a matter of fact, 2 forms when the treatment with O2 is done in the presence of triethyl phosphite as reducing agent, whereas sodium sulphite reduction affords compound 3. It has been postulated that the transformation 1 —3 occurs through the intermediacy of the peroxide 4. 

Leaves of Coleus barbatus (Andr.) Benth. (Labiateae), known as falso boldo , are used in the region as an effective hepatoprotective agent. A comparative study of the hydroalcoholic extract of leaves of C. barbatus, P. boldus ( Chilean boldo ) and boldine indicated the presence of antioxidant activity for all the samples, measured by means of an inhibition in lipid peroxidation (V. Tamasiro, personal communication). However, C. barbatus was prooxidant when tested in vivo, thus indicating that this species should not be used as it were P. boldus. 

Artichoke phenolics are good hepatoprotective agents against hepatotoxic substances [41]. 

The cyclic disulfide 4(7 )-7,7-dimethyl-l,2,5-dithiazocan-6-one-4-carboxylic acid (11) has been evaluated as a potential hepatoprotective agent for the treatment of various liver injuries <91MI 925-01). It has been shown to suppress increases in serum transaminase and alkaline phosphatase enzyme activities associated with tetrachloromethane and a-naphthyl isocyanate induced chronic liver damage in rodents <9lMi 925-02). It also assists in the elimination of hepatic viruses from livers of patients with chronic active hepatitis <9lMl 925-03). 

Hartwig W, Bom L (1987) Diastereoselective and Enantioselective Total Synthesis of the Hepatoprotective Agent Clausenamide. J Org Chem 52 4352... 

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