Monooxygenases, hepatic

Fent, K., Woodin, B.R., and Stegeman, J.J. (1998). Effects of triphenyl tin and other organotins on hepatic monooxygenase system in fish. In D.R. Livingstone and J.J. Stegeman (Eds.) Forms and Functions of Cytochrome P450, 277-288. 

Leopard frog, Rana pipiens adults single ip injection of PCB 126 at 0.0.0.2, 0.7, 2.3, or 7.8 mg/kg BW. Four hepatic monooxygenases were examined After 1 week, specific activities were not affected at 0.7 mg/kg BW and lower, but were 3-6.4 times higher than controls at 2.3 mg/kg BW and higher — and remained elevated for at least 4 weeks 20... 

Gooch, J.W., A.A. Elskus, PJ. Kloepper-Sams, M.E. Hahn, and JJ. Stegman. 1989. Effects of ortho- and non-orf/to-substituted polychlorinated biphenyl congeners on the hepatic monooxygenase system in scup (,Stenotomus chrysops). Toxicol. Appl. Pharmacol. 98 422-433. 

Korte, M., Stahlmann, S.R., Neubert, D. Induction of hepatic monooxygenases in female rats and offspring in correlation with TCDD concentrations after single treatment during pregnancy, Chemosphere, 20, 1193, 1990. 

Nearly all of the microbial and mammalian transformation studies with this group of alkaloids have been focused on nicotine. Microorganisms have been used to resolve racemic nicotine to make available unnatural (/ )-(+)-nicotine for biological evaluation. Highly significant work has detailed the mechanism of nicotine oxidation in mammals, and has resulted in the identification of reactive intermediates formed as the alkaloid is transformed by hepatic monooxygenases. The chemistry and pharmacology of the pyridine alkaloids is discussed by Strunz and Findlay in Volume 26 of this treatise. 

Trautman, T.D., Ph. D. dissertation "Disposition of p-Nitro-anisole in Mice Mus musculus for Assessment of Hepatic Monooxygenase Capability", Univ. of California, Davis (1978)... 

Other Toxicity Concerns. Additional toxicity concerns include interference with normal metabolism and function of mucosal cells, for example, water absorption by these cells [80]. The unconjugated bile acids are known to block amino acid metabolism [81] and glucose transport [82]. There is a possibility of biotransformation of these enhancers to toxic or carcinogenic substances by hepatic monooxygenases [83]. Absorption of permeation enhancers into the systemic circulation can also cause toxicity, for example, azone [84] and hexamethylene lauramide [85] which are absorbed... 

When given orally, 8% of the amaranth is absorbed from the intestinal tract. Intestinal flora have a reducing effect on amaranth, and azo reduction is also mediated by the hepatic monooxygenase system. Aromatic amine metabolites, including 1-amino-4-naphthalene sulfonic acid and l-amino-2-hydro-xy-3,6-naphthalene disulfonic acid, are excreted in the urine and bile. 

JB Tomazewski, DM Jerina, JW Daly. Deuterium isotope effects during formation of phenols by hepatic monooxygenases evidence for alternative to the arene oxide pathway. Biochemistry 14 2024—2031, 1975. 

Bulger, W.H., R.M. Muccitelli and D. Kupfer. Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites role of hepatic monooxygenases in rats and humans. Biochem. Pharmacol. 

Oliw, E.H., l.D. Brodowsky, L. Hornsten, and M. Hamberg (1993). Bis-allylic hydroxylation of polyunsaturated fatty acids by hepatic monooxygenases and its relation to the enzymatic and nonen-zymatic formation of conjugated hydroxy fatty acids. Arch. Biochem. Biophys. 300, 434-439. 

Clarke, L. and D.J. Waxman (1989). Oxidative metabolism of cyclophosphamide Identification of the hepatic monooxygenase catalysts of drug activation. Cancer Res. 49, 2344-2350. 

Oliw, E.H. (1993). Ws-Allylic hydroxylation of linoleic acid and AA by human hepatic monooxygenases. Biochim. Biophys. Acta 1166, 258-263. 

I can, M., Ooban, T., Eke, B.C., 1995. Differential responses of hepatic monooxygenases and glutathione S-transferases of mice to a combination of cadmium and nickel. Comp. Biochem. Physiol. 111C, 61-68. 

---