Hepatic lesions carcinogenesis

Malins DC, MM Krahn, MS Myers, LD Rhodes, DW Brown, CA Krone, BB McCain, S-L Chan (1985) Toxic chemicals in sediments and biota from a creosote-polluted harbor relationships with hepatic neoplasms and other hepatic lesions in English sole (Parophrys vetulus). Carcinogenesis 6 1463-1469. 

Some information on structure-promotion relationships for PBBs is available from studies that used two-stage liver and skin carcinogenesis models. In the liver promotion studies, development of enzyme-altered hepatic foci (putative preneoplastic lesions) was assessed in rats that were partially hepatectomized, initiated with diethylnitrosamine and promoted with PBBs (Buchmann et al. 1991 Dixon et al. 1988 ... 

The basic fraction of tryptophan pyrolysate was also tested by oral administration to Wistar rats over 2 years (40). The most advanced lesions obtained at the higher (but not the lower) dose were neoplastic nodules in the liver, an intermediate step in the process of hepatic carcinogenesis. The authors state that, historically, pre-neoplastic lesions in rats of this strain have never been seen in their laboratory without administration of carcinogens. Trp-P-2, as a pure compound, has also been tested in ACI rats in a lifetime (870 days) study (41). In this study, 10 male and 9 female animals survived more than 400 days on a diet containing 0.01% Trp-P-2. Neoplastic nodules were again seen in the livers of treated females, but none occurred in the males of the experimental group or any of the control animals. 

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