Heparin methylation

Table 9. Thromboresistance of heparin-(methyl methacrylate) copolymers 93 ...

Second, bromination of methyl groups attached to arylphenoxy-phosphazene polymers converted them to CH2Br units (22). These were then quaternized with triethylamine, and the quaternary sites were used for anion exchange with sodium heparin (Fig. 2). The... 

Free hydroxyl groups of heparin have been caused to react with methyl iodide, to afford methoxyl derivatives,100,101,264 with chlorosul-fonic acid-pyridine266 or chlorosulfonic-sulfuric acid,267 to give su-persulfated heparins, and with methacryl chloride, to provide a water-soluble, heparin methacrylate268 that can be condensed to heparin polymers. 

Table 2. Immobilization of heparin using the procedure involving tridodecyl methyl ammonium chloride53 ...

The free amino groups of a polymer, poly-p-aminostyrene for instance quaternized with methyl iodide are also capable of binding heparin 81). 

A perspective method for the production of HCP was proposed by Labarre et al 92-94) [t invo]ves radical graft-copolymerization of methyl methacrylate onto heparin effected by cerium salts (Ce4+). As well as other hydroxyl-containing polymers, heparin may react with cerium ions producing free radicals which may initiate graft-copolymerization of unsaturated compounds ... 

Prochlorperazine Edisylate Prochlorperazine edisylate is not compatible with sodium chloride solutions containing methyl hydroxybenzoate and propyl hydroxy-benzoate as preservatives, but is compatible with solutions containing benzyl alcohol. Prochlorperazine edisylate salts are incompatible with a number of drugs such as aminophylline, amphotericin, ampicillin sodium, some barbiturates, ben-zylpenicillin salts, calcium gluconate, cefmetazole sodium, cephalothin sodium, chloramphenicol sodium succinate, chlorothiazide sodium, chloramphenicol, morphine sulfate containing phenol, magnesium trisilicate mixture, sodium succinate, chlorothiazide sodium, dimenhydrinate, heparin sodium, hydrocortisone sodium succinate, midazolam hydrochloride, and some sulfonamides.166... 

Passirani, C., L. Ferrarini, et al. (1999). Preparation and characterization of nanoparticles bearing heparin or dextran covalently-linked to poly(methyl methacrylate). J Biomater Sci Polym Ed 10(1) 47-62. 

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