Hemolytic foci

Campbell, P. A. Heterogeneity of antibodies produced by single hemolytic foci. Cell Immunol. 2, 250-258 (1971). 

Vann, D. C., Campbell, P. A. Plaque-forming cells of two different origins in single hemolytic foci. J. Immunol. 105, 1584-1586 (1970). 

Acute lethality data for inhalation exposure to monomethylhydrazine are available for monkey, dog, rat, mouse, and hamster. Based upon the available data, hamsters appear to be the most resistant species, and the squirrel monkey and beagle dog are the most sensitive. The lethality of monomethylhydrazine appeared to follow a linear relationship for exposures up to 1 h. Most animal data focus on lethality as the toxicity endpoint with very limited exposure-response information available regarding nonlethal effects. The most significant effect reported in the acute exposure studies was the notable hemolytic response that was reversible upon cessation of exposure. However, the preponderance of the data suggest that there is little margin between exposures associated with nonlethal, reversible effects and those that result in death. 

Treatment of hemolytic anemia should focus on correcting the underlying cause. There is no specific therapy for glucose-6-phosphate dehydrogenase deficiency, so treatment consists of avoiding oxidant medications and chemicals. Steroids, other immunosuppressants, and even splenectomy can be indicated to reduce RBC destruction. 

Many structure—activity relationship studies of host defense peptides have also focused on LL-37. Importantly, LL-37 has a broad spectrum of activities within the immune system but has also displayed cytotoxic activities that would diminish the therapeutic application of this peptide. Thus, structure—activity studies of LL-37 have focused on this cytotoxicity. A study by Nagaoka et al has demonstrated that the cytotoxic and hemolytic activities of LL-37 may reside within different regions of the peptide. Using an 18-mer... 

Pharyngitis is an acute infection of the oropharynx or nasopharynx. It results in 1% to 2% of all outpatient visits. While viral causes are most common, group A /3 -hemolytic Streptococcus, or S. pyogenes, is the primary bacterial cause and is the focus of this section. In the pediatric population, group A Streptococcus, or strep throat, causes 15% to 30% of cases of pharyngitis. In adults, it is the cause of 5% to 15% of all symptomatic episodes of pharyngitis. ... 

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