Hemoglobin analogy

Another artificial blood product named PolyHeme was submitted for FDA approval by its manufacturer, Northfield Labs, in August 2001. PolyHeme is produced by extracting hemoglobin from red blood cells, filtering them to remove impurities, and then modifying them chemically to produce the polymerized hemoglobin analog. 

In an analogous way the influence of alcohol on the kinetics of thermal denaturation of met-hemoglobin was studied successfully144). 

A series of bonded poly(alkyl aspartamide) coatings was prepared on silica by analogy to the method described above. Poly(succinimide) coating was reacted with n-alkyl- and arylalkylamines in dimethylformamide to yield a series of hydrophobic adsorbents. Poly(propyl aspartamide)-silica (PolyPROPYL A) showed the maximal reversible hydrophobic binding of hemoglobin among the Cl -C5... 

Collman JP, Boulatov R, Sunderland CJ. 2004a. Eunctional analogs of cytochrome c oxidase, myoglobin and hemoglobin. Chem Rev 104 561. 

The structures of the oxime complex Co(NO)(dmg)2 (84) and its diphenylglyoxime analog exhibit strongly bent Co—NO groups, which are easily oxidized to the corresponding nitro compound.353 A mechanistic study of NO transfer from Co(NO)(dmg)2 to hemoglobin established that the reaction involves NO association with the protein subsequent to dissociation of NO from the Co complex.354 This mechanism is also consistent with the observation of nitrato complexes in reactions... 

The Ni-ligand mode can be identified as the Ni-axial ligand stretch because of the close analogy between the Ni isotopic substitution results and the Fe-isotope substitution data for native hemoglobin and myoglobin (27-30). For the native proteins myje complete isotope substitution studies including N- N... 

In 1847 E. Harless discovered the presence of copper in the blood of the octopus Eledone and the snail Helix pomatia (172, 173). Investigation of the phenomenon by which the blood and tissues of certain marine animals turn blue on exposure to air finally led to the discovery that the blood plasma of such animals contains copper combined with a protein. Because of its analogy to hemoglobin and its ability to carry oxygen, L. Fredericq in 1878 named the copper-containing protein in the blood of Octopus vulgaris hemocyanin (173, 174). 

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