Polymerized hemoglobins

Ferrone FA, Hofrichter J, Eaton WA. Kinetics of sickle hemoglobin polymerization II. A double nucleation mechanism. J Mol Biol 1985 183 611-633. 

HEMOGLOBINS POLYMERIZATION DELOCALIZATION Delocalization of a free electron pair, n (7 DELOCALIZATION HYPERCONJUGATION RESONANCE "DELPHI,"... 

HEMOGLOBINS POLYMERIZATION RESONANCE RAMAN SPECTROSCOPY HEMOGLOBIN-S POLYMERIZATION HENDERSON-HASSELBALCH EQUATION HENDERSON PLOT Henri-Brown treatment,... 

MICROSCOPIC DIFFUSION CONTROL MACROSCOPIC DIFFUSION CONTROL MICROSCOPIC REVERSIBILITY CHEMICAL REACTION DETAILED BALANCING, RRINCIRLE OF CHEMICAL KINETICS MICROTUBULE ASSEMBLY KINETICS BIOCHEMICAL SELF-ASSEMBLY ACTIN ASSEMBLY KINETICS HEMOGLOBINS POLYMERIZATION... 

In the majority of patients with sickle cell disease, anemia is not the major problem the anemia is generally well compensated even though such individuals have a chronically low hematocrit (20-30%), a low serum hemoglobin level (7-10 g/dL), and an elevated reticulocyte count. Instead, the primary problem is that deoxygenated HbS chains form polymeric structures that dramatically change erythrocyte shape, reduce deformability, and elicit membrane permeability changes that further promote hemoglobin polymerization. Abnormal erythrocytes... 

Josephs R Research on sickle cell hemoglobin, virtual tour of sickle hemoglobin polymerization. Laboratory for Electron Microscopy at the University of Chicago, 1999. Available at http // gingi. uchicago. eduZsc2-tourl.htm, 2004. 

Eaton, W. A., and Hofrichter, J. 1990. Sickle cell hemoglobin polymerization. Adv. Prot. Chem. 40 63 279. 

Ferrone, F. A. Hofrichter, J. Eaton, W. A. 1985a. Kinetics of Sickle Hemoglobin Polymerization I. Studies Using Temperature-Jump and Laser Photolysis Techniques, J. Mol. Biol. 183, 591-610. 

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