Hematotoxicity In Vitro and Ex Vivo Compound Profiling

The main target organs for compound toxicity leading to either drug withdrawal or arrest of compound development as estimated in various studies [3], are classically pointing at liver, the cardiovascular system and bone marrow (hematotoxicity). Cardiovascular and hepatotoxicity were discussed in previous chapters and this chapter focuses on hematotoxicity. 

Hematotoxicity, defined as drug-induced altered production of peripheral blood cells, is most commonly associated with antiproliferative oncology compounds but is also caused by drugs for various indications, covering a wide pharmacology and chemical structure diversity (Table 17.1). This vast variety of chemical structures makes it difficult to predict hematotoxicity by in silica approaches and to model 

Hit and Lead Projiling. Edited by Bernard Faller and Laszlo Urban Copyright 2009 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 978-3-527-32331-9 

Analgesic and Acetylsahcylic acid, aminopyrine, benoxaprofen, dipyrone, bucilla- 

Anticonvulsant Carbamazepine, ethosuximide, lamotrigine, mesantoin, phenytoin, trimefhadione, valproic acid 

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