Hematopoietic syndrome

Gy Hematopoietic syndrome characterized by bone marrow damage, anemia, lowered immune response, hemorrhage, and sometimes death 20... 

The blood-forming organs are among the most sensitive to the effects of radiation, so these organs are among the first to show the results of high radiation exposure. Hematopoietic syndrome begins to appear at doses of... 

Hematopoietic syndrome Changes in blood cell count from damage to crypt cells, severe radiation sickness, recovery possible with medical support. 

Ibeatment for patients suffering from hematopoietic syndromes includes replacing blood cells via transfusion, isolation from sources of infection, and antibiotic treatment. 

In most cases, bone marrow cells begin to replicate full recovery for a large % of individuals from a few weeks up to 2 years after exposure. Death may occur in some patients at 1.2Gy (120rads) the LDjo,5o is about 2.5-5 Gy (250-500rads). Sepsis and hemorrhage are primary causes of death At doses greater than 12 Gy, mortality rate exceeds that of hematopoietic syndrome death due to infection, dehydration and electrolyte imbalance within 2 weeks of exposure the LD is about 10 Gy (1,000 rads)... 

Some skin damage frequently accompanies ARS. However, the cutaneous syndrome can also result from localized acute radiation exposure to the skin, usually from direct handling of radioactive sources or from contamination of the skin or clothes (2,8) (see Figs. 4.1 and 4.2) With localized exposure, even with high doses, the victim frequently survives, because the whole body usually does not receive the localized dose. However, if a patient with localized radiation induced cutaneous injury has also received whole body irradiation from an external source, the cutaneous damage increases the risk for death from the whole body exposure (2). Patients with the hematopoietic syndrome due to whole body irradiation will recover more slowly, if at all, from cutaneous injury due to bleeding, infection and poor wound healing (2). 

A. Hematopoietic Syndrome. Patients who have received doses of radiation in the low to mid-lethal range will have depression of bone-marrow function with cessation of blood-cell production leading to pancytopenia. Among treated patients, deaths should be minimal. 

In addition, the documented radioprotectant activity of Cu(II)(3,5-DIPS)2 [505] is consistent with its anti-inflammatory activity [22, 84, 514], which relates to protection against the hematopoietic syndrome, its antiulcer activity [22, 84, 91, 514-516], which relates to its potential ability to protect against the gastrointestinal syndrome, and its anticonvulsant activity [324, 326, 516], which relates to its potential to protect against the central nervous system syndrome. 

Gastrointestinal (Gl) syndrome can result after acute exposure to 10 Gy or less. The radiation exposure causes destruction of the epithelial lining of the GI tract, and Gl syndrome is characterized by lethargy, diarrhea, dehydration, degeneration of bowel epithelium, and death in 10-14 days (NCRP, 1989). The other syndrome associated with acute exposure is hematopoietic syndrome, which may present days to weeks after total body radiation exposure ranging from 2.5 to 5 Gy. The hematopoietic syndrome is characterized by granulocytopenia, thrombocytopenia, hemorrhage, infection, and electrolyte imbalance. Even lower doses (1-5 Gy) can cause hematopoietic syndrome, which results in what... 

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