HBOCs

For infants aged 7 to 11 months who have not been vaccinated, three doses of HbOC, PRP-OMP, and PRP-T should be given two doses, spaced 4 weeks apart, and then a booster dose at age 12 to 15 months (but at least 8 weeks since dose 2). For unvaccinated children aged 12 to 14 months, two doses should be given, with an interval of 2 months between them. In a child older than 15 months, a single dose of any of the four conjugate vaccines is indicated. 

HbOC HibTITER (Wyeth Vaccines) Mutant diphtheria toxin protein... 

Manley GT, Hemphill JC, Morabito D, et al. Small-volume resuscitation with the hemoglobin substitute HBOC-201 effect on brain tissue oxygenation. Adv Exp Med Biol 2003 530 311. 

Pearce LB, Gawryl MS. The pharmacology of tissue oxygenation by biopure s hemoglobin-based oxygen carrier, Hemopure (HBOC-201). Adv Exp Med Biol 2003 530 261. 

Biopure Corp. (USA) Glutaraldehyde-polymerized bovine Hb (HBOC-201 or Hemopure ) Surgery... 

Based on investigators recommendations, the effects of increasing doses of HBOC-201 were assessed in two subsequent studies.After the induction of anesthesia, collection of 1 L of blood, and the infusion of 1 L of RL solution, 24 patients (12 in each study) were randomly assigned to receive, within 30 min, a 6.9- or 9.2-ml/kg dose of either HBOC-201 or 6% HES. (Patients infused with Hb received either 0.9 or 1.2gHb/kg, respectively.) Then, patients received an additional 500 ml of RL solution to maintain intravascular volume. As before, patient data relative to systemic and pulmonary arterial pressures and arterial and mixed venous blood gases were used to calculate... 

At -1-48 h and in the saline group, these differences were not observed. Likewise, at +4h there was a smaller rise in the lactate level of the HBOC-201 subjects as compared to the baseline period this difference was not statistically significant, nor was it observed at +48 h or in the placebo group. 

Thus, this study in sickle cell disease patients appeared to support the findings of a parallel study in normal human volunteers, where it was concluded that HBOC-201 apparently supported submaximal exercise capacity in a manner quite similar to autologous blood, but at lower pulse rate. Cl, and lactate concentration. The results of both studies suggest that the provision of acellular Hb may be an efficient way to deliver oxygen to the tissues. 

Although preliminary data from clinical trials of Hb-PHP or HBOC-201 are not available, it is reasonable to anticipate that as these tHbs are cleared from the circulation and metabolized, total bilirubin in the plasma will increase and then decline. 

Wahr, J.A. Anderson, M.M. Giacherio, D.A. Hallock, L. Gawryl, M.S. Lansden, C. Tremper, K.K. The effects of a blood-salvaging device on blood containing a hemoglobin-based oxygen carrier, HBOC-201. J. Cardiothorac. Vase. Anesthes. 1997, 11 (1), 10-12. 

HbOC vaccine (Hib oligosaccharides linked to the non-toxic diphtheria toxin variant CRM197), for example HibTITER (produced by Lederle-Praxis Biologicals, Pearl River, NY). 

In a study of the tolerability and immunogenicity of Hib vaccines, 30 volunteers aged 69-84 years were immunized with either Pedvax-Hib (a conjugate of Hib polysaccharide and an outer membrane protein complex of Neisseria meningitidis-YR -OMP) or Hib TITER (a conjugate of Hib oligosaccharide and a non-toxic mutant diphtheria toxin, CRM 197-HbOC) (4). The volunteers... 

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