Hallucinogens physiological effects

There is little information about the toxicity of 2C-B as there are only a limited number of studies done on the drug. However, some conclusions can be draw about its physiological effects based on studies of drugs that are chemically similar to 2C-B. The drug binds to serotonin receptors in the brain, which is why it has hallucinogenic properties. Serotonin is a neurotransmitter or messenger substance that carries information through the peripheral and central nervous systems. 

Gingrich JA, Zhou M, Sealfon SC, Hen R. Mice lacking 5-HT2A receptor are insensitive to many of the behavioral and physiological effects of hallucinogens. Soc Neurosci Abstr 1999 25 799. 

The physiological effects of LSD and related hallucinogens arc generally similar to those of amphetamine and cocaine that is, they are sympathotnimetic. Thus, the effects include pupil dilation, increased heart rate and blood pressure, increased body temperature, and increased sweating (Grinspoon Bakalar, 1979). 

Anticholinergic hallucinogens produce a variety of physiological effects, including dry mouth, blurred vision, loss of motor control, and increased heart rate and body... 

In contrast to 3-phenylethylamines such as mescaline (4), isoquinoline alkaloids do not have hallucinogenic activity. These alkaloids are toxic to many animals and exhibit a number of other physiological effects. Both peyophorine (15) and camegeine (18) have positive inotropic effects and modify heart action in mammals (Wagner, 1988). Other isoquinoline alkaloids have been reported to possess antitumor activity (Lundstrom, 1983). 

Little is known specifically about the effects of mescaline compared to LSD. Much information about it relies upon its similarities with other monoamine hallucinogens. The majority of attention is given here to mescaline, but some brief mention of the diverse effects of other peyote alkaloids (of which little is known) is deserved. Often, their effects are very different from mescaline. Many alkaloids are present in sufficent concentrations to alter human physiology after oral consumption of peyote. Lophophorine in humans causes a "sickening feeling in the back of... 

The actions of Salvia divinorum on the physiology of the body have not been studied as of 2002 and are thus unknown. However, other hallucinogenic substances have substantial effects on the autonomic nervous system, the part of the nervous system that governs bodily functions. These effects may include dilation of the pupils, blurred vision, tremors, uncoordination, elevated heart rate, heart palpitations, elevated body temperature, and sweating. 

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