Halides alkynes

Vinylic halide, alkynes from, 261 S 2 reaction and, 366-367 Vinylic protons, NMR... 

Scheme 9.1 Synthesis of aiienyimetai compounds from propargylic halides, alkynes, and allenes.

Alkenes, Cyclic Alkenes, and Dienes Alkenes, Cyclic Alkenes, and Dienes Ethylene Propylene Alkyl Halides Alkynes Aluminum Americium Amides Amides Carbofuran Dimethyl Acetamide Amines Antimony... 

Evidence based on product mixtures now suggests, at least in the cases of a-halocarbonyl and perhaloalkyl starting marterials, that these reactions are in fact atom transfer radical cyclizations (equation 166)324,325. In them, the palladium catalyst is proposed to have roles both as the radical initiator and as a trap for iodine, similar to the more commonly used hexabutylditin. Intramolecular allyl halide-alkyne cyclizations proceed with trans-addition to the triple bond this is evidence that a still different mechanism may be operating in these cases (equation 167)1,326. 

The relationship between log A ow and log S for various classes of organic compounds is shown schematically in Fig. 1, along with the ideal line for the octanol-water system. The data for organic liquids (classes 1-9) are those of Hansch et al. (44), in which most partition coefficients are calculated values. Imprecise as some of these data may be, they nevertheless form a useful basis for illustrating the characteristic behavior of organic liquids in the octanol-water system. Alcohols and ethers approach ideal behavior apparently because their structure and polarity are similar to octanol. Over the range of the solute solubility reported, the deviation of ketones, esters, alkyl halides, alkynes, and... 

Liu Z, Larock RC (2007) Palladium-catalyzed, sequential, three-component cross-coupling of aryl halides, alkynes, and arynes. Angew Chem Int Edit 46 2535-2538. doi 10.1002/ anie.200604969... 

Alkyl halides react with a variety of nucleophiles to give alcohols, ethers, alkyl halides, alkynes, and other families of compounds. Examples are shown in Table 6.1 and Section 6.2. 

B.viii. Divalent Palladium-Catalyzed Halide-Alkyne-o,/3-Unsaturated Carbonyl Coupling... 

Just as alkenes can be prepared from alkyl halides, alkynes can be prepared from alkyl dihalides ... 

Keywords Alkyl halides, alkynes, sodium azide, CU2O, methanol, room temperature, multi-component reaction, click synthesis, heterocycles, substituted 5-alkynyl 1,2,3-triazoles... 

Pd°-catalyzed reaction between aryl halides, CO, and KCN (Scheme 35). ° The tandem four-component assembly is possible for the combination of aryl halides, alkynes, CO, and KCN, which yields /3-aryl substituted alkenoyl cyanides by the catalysis of Pd° (Scheme 36). ... 

In addition to the numerous examples of the McMurry couplings described above, the following examples illustrate the power of the transformation in the synthesis of a broad range of natural products and non-natural molecules. Of particular note in the following examples is the impressive functional group tolerance of the McMurry conditions. In general, alcohols, tosyl alcohols, alkyl ethers, silyl ethers, alkyl silanes, vinyl silanes, amines, sulfides, and alkenes are inert to McMurry conditions. Acteals, halides, alkynes, nitriles, and carboxylic acids are semi-compatible. 

Amine, Alcohol, Aldehyde, Alkane, Alkene, Alkyl Halide, Alkyne, Carboxylic Acid, Epoxide, Ether, Ketone, Nitrile (cyano), Nitro, Phenyl Group (benzene ring) and Thiol. 

The reaction of aryl/alkyl halides, alkynes, and sodium azide in water may be catalyzed by a heterogeneous copper(l) catalyst, oyster shell powders (OSPs)-CuBr (2.5mol%), and microwave irradiation (480 W and 70 °C). The catalyst could be easily recovered from the reaction mixture by a simple filtration and reused at least eight times without significant loss of its catalytic activity. Chitin and protein molecules on OSP particles surface seem to play important roles in the chelation of the CuBr species [112]. 

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