Guinea pig maximisation test

Certain strains of inbred guinea-pigs can be sensitized to mercuric chloride, and the ability to become sensitized appeared to be transmitted as a dominant characteristic which was not sex-linked [210-212]. By the guinea-pig maximisation test and using a mercuric chloride concentration of 0.1%, a sensitization rate of 8/25 was found and mercuric chloride was graded as a moderate sensitizer [213],... 

Magnussun B, Kligman AM. The identification of contact allergens by animal assay. The guinea pig maximisation test, f Invest Dermatol 1969 52 268-76. 

In primary irritation tests no or only slight effects were seen at the skin or in the eyes of the treated rabbits respectively [3.213], [3.214], No skin sensitisation occurred in a Guinea pig maximisation test [3.211]. 

Food and Drug Administration (1972) United States - Food and Drug Administration. Hazardous substances. Proposed revisions of test for primary skin irritants. Fed Reg 37 27635 Frankild S, Basketter DA, Andersen KE (1996) The vdue and limitations of rechallenge in the guinea pig maximisation test. Contact Dermatitis 35 135-140... 

DGEBA, with a MW of 340 Da. In the guinea-pig maximisation test, the oligomer with a MW of 624 Da was also a sensitiser, but it had minor sensitising capacity, whereas oligomers with a MW of more than 900 Da did not induce sensitivity (Thorgeirsson et al. 1978). 

In the guinea-pig maximisation test, polyamine hardeners with a low MW were found to be strong sensitisers (Thorgeirsson 1978b). Most of the patients with contact allergy to epoxy hardeners react to 4,4 -... 

There are a number of models for detecting allergic contact dermatitis in guinea pigs. The maximisation test developed by Magnussun and Kligman is the most widely used and employs both an intradermal and topical sensitisation phase, together with the non-specific stimulation of the immune system by the intradermal injection of Freund s complete adjuvant. 

Mercier, O. 1990b. HFA-134a Test to Evaluate the Sensitising Potential by Topical Applications in the Guinea Pig. The Epicutaneous Maximisation Test. Rep. No. 001380. Hazelton Laboratories, France. 

The skin irritancy of MTBE has been demonstrated in most studies [66, 67,73-75] whereas ETBE is not a skin irritant according to studies conducted to OECD guidehnes [76-78]. No sensitising potential was demonstrated for MTBE [66,67,79] or ETBE in a maximisation test in guinea pigs [80]. 

For humans, the most widely known methods are the human maximisation test (HMT) and the modified Draize repeated-insult patch test (Kligman 1966 Marzulli and Maibach 1973). GPMT and HMT were developed in parallel and the results were in close conformity, which has been adduced as support for extrapolating guinea pig findings to man. 

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