Human maximisation test

For humans, the most widely known methods are the human maximisation test (HMT) and the modified Draize repeated-insult patch test (Kligman 1966 Marzulli and Maibach 1973). GPMT and HMT were developed in parallel and the results were in close conformity, which has been adduced as support for extrapolating guinea pig findings to man. 

In the last 50 years, skin sensitisation potential assessment has been of paramount importance for ensuring the safety of cosmetic products. Different human sensitisation tests, such as Schwartz-Peck test (Schwartz, 1969), human repeated insult patch tests (Marzulli and Maibach, 1973 Griffith and Buehler, 1976) and human maximisation test (Kligman and Epstein, 1975), have been used but standardised test guideUnes are not available and the tests have not undergone an official validation process. 

---