Growth-inhibition effects

Microbiol Stability. Microbial growth is hindered by reducing water activity and adding preservatives. An overview is available (30). Reduction in water activity is typically obtained by including approximately 50% of a polyalcohol such as sorbitol or glycerol. Furthermore, 20% of a salt like NaCl has a pronounced growth inhibiting effect. 

Coumarin, the lactone of o-hydroxycinnamic acid, and some of its derivatives have been isolated from many plant species 31). Thimann and Bonner 141) attributed the growth-inhibiting effects of coumarin to its action on enzyme sulfhydryl groups. Inhibitory effects of coumarin on Avena coleoptiles and pea stem sections could be overcome by 2,3-dimercaptopropanol (BAL). Coumarin has also been reported to disrupt mitosis 29,30). 

Weyers, A. and Vollmer, G. (2000) Algal growth inhibition effect of the choice of growth rate or biomass as endpoint on the classification and labelling of new substances notified in the EU, Chemosphere 41 (7), 1007-1010. 

Lee, H.S. and Ahn, Y.J. (1998) Growth inhibiting effects of Cinnamomum cassia bark derived materials on human intestinal bacteria. Journal of Agricultural and Food Chemistry 46, 8-12. 

PolyPs display antiseptic, cytoprotective and antiviral activities. At a concentration of 0.1 % or higher, PolyP had a bacteriocidal effect on log arithmic-phase Bacillus cereus cells (Maier et al., 1999). The growth inhibition effect of PolyP was observed with Staphylococcus aureus (Jen and Shelef, 1986 Matsuoka et al., 1995) and Aerornonas hydrophila (Palumbo et al., 1995). 

IM PDH. At doses as high as 100 jjlM, 62 did not show in vitro growth inhibition effects against cancer cells in the NCI s disease-oriented screening program [58],... 

Certain strains of bacteria are resistant to the lytic properties of penicillins but remain. su.sccptible to their growth-inhibiting effects. Thus, the action of the antibiotic has been converted from bactericidal to bacteriostatic. This mechanism of resistance is termed tolerance and apparently results from impaired autolysin activity in the bacterium. 

Sundman, V., and Sundman, J., Bacterial growth inhibiting effect of some phloroglucinol derivatives. Acta Pathol. Microbiol. Scand. 53, 345-355 (1961). 

Table 1. Antifeedant and growth inhibition effects of P. indica ethanolic extract on several insect species...

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