Growth factors, cholinergic system

Backman, C., Rose, G.M., Hoffcr, B.J., Henry, M.A., Bartus, R.T., Friden, P., and Granholm, A.-C. (1996) Systemic administration of a nerve growth factor conjugate reverses age-related cognitive dysfunction and prevents cholinergic neuron atrophy./. Neurosci. 16, 5437. 

Hawkes C, Kar S. 2003. Insulin-like growth factor-II/mannose-6-phosphate receptor widespread distribution in neurons of the central nervous system including those expressing cholinergic phenotype. J Comp Neurol 458 113-127. 

BDNF brain derived neurotrophic factor is a member of the nerve growth factor family of trophic factors. In the brain, BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994). 

Korsching, S.,Auburger, G.,Heumann, R., Scott, J., and Thoenen, H., Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation, EMBO J., 4, 1389, 1985. 

Pioro EP, Cuello AC (1990) Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system. II. Brainstem, cerebellum and spinal cord. Neuroscience, 34, 89-110. 

THYROID HORMONES AND NEUROTRANSMITTER SYSTEMS AN INTERACTION WITH NERVE GROWTH FACTOR IN THE REGULATION OF CHOLINERGIC NEURONES... 

Neurotrophins play an important role in the normal development of the nervous system, but their function in the mature central nervous system is poorly understood. Nerve growth factor (NGF) is necessary for the survival and maintenance of the basal forebrain cholinergic system. 

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