Growth Factor Delivery for Osteogenesis

A number of delivery systems have been developed for the controlled release of bone morphogenic protein-2 (BMP-2). For example, calcimn phosphate cement-based materials have shown the ability to deliver recombinant human bone morphogenic protein-2 (rhBMP-2) to increase alkaline phosphatase (ALP) activity in MC3T3-E1 cells in vitro,and enhance bone formation both ectopically and in an ulna osteotomy model. In addition to cement-based systems, polymeric materials have also been heavily researched as potential delivery vehicles of BMP-2. Saito et al. have developed a temperature sensitive poly(D,L-lactic acid-polyethylene glycol) (PLA-PEG) block copolymer as an [Pg.436]

Biodegradable Injectable Systems for Bone Tissue Engineering 437 [Pg.437]

Delivery methods based on microparticle and nanoparticle designs have gained increased attention in the delivery of growth factors to induce osteogenesis with smaller amounts of BMP-2 and with improved release over more [Pg.437]

Carrier material Therapeutic agent Matrix type Celljanimal model Reference [Pg.437]

P-Dicalcium silicate Gentamicin Cement L929 cells 178 [Pg.437]

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