Grignard reaction with ethyl formate

Grignard reaction, (Continual) with ethyl formate, 16, I r with ethyl orthoformate, 16, 41 with water, 11, 84... 

Grignard reaction in -butyl ether, 11, 84 with acetaldehyde, 12, 48 with butyl / -toluenesullonate, 10, 4 with carbon dioxide, 11, 80 with dimethyl sulfate, 11, 66 with ethyl carbonate, 11, 98 with ethyl formate, 15, n with ethyl orthoformate, 16, 41 with water, 11, 84... 

Several improvements in acylation techniques were announced. Butyllithium wwas determined to be superior to sodium amide in preparation of amide ions for ammonolysis reactions with esters. Phosgene is more reactive than ethyl chloroformate toward eneamines. The intermediate acyl chlorides may then be converted to a variety of products. a-Acetylenic aldehydes are easily prepared by the action of acetylenic Grignard reagents upon ethyl formate. ... 

Germanium surface passivation by chloride termination inhibits oxide formation and maintains a well-ordered surface. The chloride-terminated surface can also be used as a reactive precursor for wet organic functionalization. For example, Cullen et al. [105] first demonstrated the reaction of a chloride-terminated Ge(lll) surface with ethyl Grignard as a means of ethylation for use in surface stabilization. The chlorination was performed by a mixture of Cl2 and HC1 gas with N2 above atmospheric pressures [105]. Although this resulted in approximately a one-to-one ratio of adsorbed chlorine atoms with Ge surface atoms, the high pressures resulted in severe etching of the substrate [105]. 

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