Grapefruit juice contains

Grapefruit juice contains a substance called naringine that inhibits CYP3A4 thus, if grapefruit juice in large quantities is taken together with... 

In grapefruit juice there was a wide difference between provitamin A in white and red or pink. White grapefruit juice contained approximately 8 International units of provitamin A per 100 g of juice, whereas pink and red contained 440 (55). 

Taste thresholds of 1 ppm nootkatone in water and 5-6 ppm in grapefruit juice were determined by Berry et al. (34), who stated that grapefruit juice containing 0.005% oil contains an average level of less than 0.5 ppm nootkatone, which is considerably lower than the threshold level in juice. They considered only the nootkatone present in the oil, and any nootkatone present in the oil-free juice would have added to this value. 

On the downside, grapefruit juice contains inhibitors such as bergamotin and naringin, which can drastically reduce the rate of metabolism of many drugs, leading to toxic effects from overdose However, there may be some potential here for improving drugs that are subject to excessively rapid metabolism. 

Other drugs that inhibit hepatic cytochromes P450 include chloramphenicol, cimeti-dine, clarithromycin, disulfiram, erythromycin, ethanol, grapefruit juice (contains fu-ranocoumarins), ethinyl estradiol, fluconazole, isoniazid, itraconazole, MAO inhibitors, phenylbutazone, and secobarbital. 

Citrus parodist Macfad (Rutaceae) is the botanical name of grapefruit, whose juice is widely known to affect dmg bioavaUabiUty in humans [44,129]. Grapefruit juice contains flavruioids, a large class of plant polyphenoUc secondary metabolites that have various pigmental and antimicrobial functirms, and which are also found in many other plants and vegetables. They are studied for their antioxidant, anti-inflammatory, and antimicrobial activity, and ability to prevent cardiovascular diseases. 

At pH 7, [H ] = [OH ] that is, there is no excess acidity or basicity. The point of neutrality is at pH 7, and solutions having a pH of 7 are said to be at neutral pH. The pH values of various fluids of biological origin or relevance are given in Table 2.3. Because the pH scale is a logarithmic scale, two solutions whose pH values differ by one pH unit have a 10-fold difference in [H ]. For example, grapefruit juice at pH 3.2 contains more than 12 times as much H as orange juice at pH 4.3. 

The potent carcinogen aflatoxin B1 is activated by generation of an epoxide on a dihydrofuran moiety [43]. The potent MBIs contained in grapefruit juice and in the herbal medication St J ohn s Wort are furanocoumarin compounds [44—46]. A similar moiety is also incorporated in the HIV protease inhibitor L-754,394, a potent CYP3A4 MBI [47]. 

Pouches - When using the pouch, squeeze the entire contents of the pouch into a glass or plastic container holding 2 or more ounces (% cup, 60 mL) of water or orange juice. No other liquids, including grapefruit juice, should be... 

To identify case reports containing information on drug and grapefruit juice interaction, the Adverse Event Reporting System (AERS) (2) database... 

---