Grapefruit juice interactions

Kane GC, Lipsky JJ. Drug-grapefruit juice interactions. 2000 75(9) 933-942. Mikkaichi T, Suzuki T, Tanemoto M, Ito S, Abe T. The organic anion transporter (OATP) family. Drug Metab Pharmacokinet 2004 19(3) 171-179. 

Takanaga H, Ohnishi A, Matsuo H, et al. Pharmacokinetic analysis of felodi-pine-grapefruit juice interaction based on an irreversible enzyme inhibition model. Br J Clin Pharmacol 2000 49 49-58. 

Table 4 Labeling Examples of Drug-Grapefruit Juice Interactions... 

Grapefruit Juice Interaction Reports from FDA s Postmarketing AERS... 

Information in the PI is typically based on the studies submitted by a drug s manufacturer. The FDA has also utilized spontaneous adverse event case reports as a tool in the evaluation of drug-grapefruit juice interaction labeling. Other sources of data that contribute to labeled information include studies or case reports from the medical literature. 

To identify case reports containing information on drug and grapefruit juice interaction, the Adverse Event Reporting System (AERS) (2) database... 

Appropriate information on grapefruit juice interaction appears in product labeling estrogens, lovastatin, nifedipine, and verapamil. 

No information in product labeling, but low plausibility of grapefruit juice interaction bupropion, doxazosin, gabapentin, lisinopril, risperidone, sertraline, and sibutramine. 

Product labeling indicates lack of grapefruit juice interaction, but plausibility of interaction amlodipine. 

Drugs that are already labeled for grapefruit juice interaction can also be reviewed to evaluate labeling for similar products, such as those that have... 

Kane, G.C. and Lipsky, J.J., Drug-grapefruit juice interactions, Mayo Clin. Proc., 75, 933-942, 2000. 

---