Granulocyte-macrophage precursor

Saunders, D., et al., Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophage colony-stimulating factor, J. Exp. Med. 184, 6, 2185, 1996. 

Granulocyte-macrophage colony-stimulating factor (GM-CSF) 23,000 Granulocytes and macrophage precursors... 

MIC caused dose-dependent necrosis of brain cells and muscle cells (Anderson et al, 1988) of rats in culture these findings could explain neuromuscular complaints in Bhopal victims. Exposure of mice to 1-3 ppm MIC was found to inhibit erythroid precursors, pluripotent stem cells and granulocyte-macrophage progenitor recovery from this inhibitory effect was found within 3 weeks after 1 ppm but not after 3 ppm (Hong et al, 1987). At higher concentrations of 6-15 ppm, MIC inhibited cell cycling in bone marrow, alveolar cells, and T lymphocytes (Conner et al., 1987 Shelby et al, 1987) similar data were reported by others (Tice et al, 1987 Mason et al, 1987). MIC can inhibit bone marrow cell proliferation in mice (Meshram and Rao, 1988). MIC can cause necrosis in whole-brain cell cultures (Anderson et al, 1990) and inhibit differentiation in muscle cell cultures (Anderson et al, 1988). 

Enhances survival, proliferation and differentiation of multipotential stem cells and committed precursors of the granulocyte, macrophage, erythroid, eosinophil, neutrophil, megakaryocyte, mast cell and basophil lineages Enhances effector functions of myeloid end cells such as phagocytosis and cytotoxicity... 

C28. Clutterbuck, E. J., and Sanderson, C. J. Regulation of human eosinophil precursor production by cytokines A comparison of recombinant human interleukin-1 (rhlL-1), rhlL-3, rhlL-S, rhlL-6, and rh granulocyte-macrophage colony-stimulating factor. Blood IS, 1774-1779 (1990). 

Main target cells Neutrophils. Also other haemopoietic progenitors and endothelial cells Macrophages and their precursor cells Haematopoietic progenitor cells Granulocytes Monocytes Endothelial cells Megakaryocytes T-lymphocytes Erythroid cells... 

Immature bone marrow precursor cells such as the myeloblast (first recognizable cell of granulocytic differentiation), promyelocyte, myelocyte, and erythroblast are thought to be capable of rephcation. This is in contrast to most mature hematopoietic cells, which are incapable of division. Exceptions to the latter statement include monocytes, macrophages, and tissue mast cells. Evaluation of reasons for... 

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