Granules proteins

Van Nostrand W. E Schmaier A. H., Farrow J. S., Cunningham D. D. Protease nexin-0 (amyloid (3-protein precursor) A platelet a granule protein. Science 1990 248,745-8. 

Eosinophils migrate to the airways and release inflammatory mediators (leukotrienes and granule proteins), cytotoxic mediators, and cytokines. 

Experiments by Peter Elsbach and colleagues in the 1970s showed that although E. coli lost viability very quickly after incubation with neutrophils, these non-viable organisms still retained several important biochemical functions, such as membrane transport and macromolecular biosynthesis. As these functions are associated with the inner plasma membrane of the bacteria, these observations suggested that the lethal hit on E. coli by neutrophils occurred on the outer membrane. Because disrupted neutrophils also affected the bacteria in this way, it was concluded that the process was independent of the respiratory burst hence these workers investigated the granule proteins for the source of this activity (reviewed in Elsbach Weiss, 1983). 

Other platelet membrane glycoproteins that are involved in adhesion reactions are GPIV and GPVI, which play a role in platelet interactions with and activation by collagen (6, 7). GPIV also functions as a receptor for the platelet alpha granule protein thrombospondin (2, 7, 8). Table 1 summarizes the functions of platelet membrane receptors. 

Roep, B. O., Arden, S. D., de Vries, R. R. P., and Hutton, J. C. (1990). T-cell clones from type 1 diabetes patient respond to insulin secretory granule proteins. Nature (London) 345, 632-634. 

Morgan R, Costello R, Durcan N, Kingham P, Gleich G, McLean W, Walsh M. 2005. Diverse effects of eosinophil cationic granule proteins in IMR-32 nerve cell signaling and survival. Am J Respir Cell Mol Biol. 33 169-177. 

Protease nexin 2 is identical to the secreted form of the amyloid precursor protein containing the Kunitz-type serine protease inhibitor domain (128,129), Protease nexin 2 circulates in blood stored as a platelet a-granule protein, which is secreted upon platelet activation (127). Protease nexin 2 inhibits trypsin- and chymotrypsin-like serine proteases and is also a potent inhibitor of factor Xla (126,127,128). Its location in platelets and its ability to inhibit factor Xla suggests a role in regulating blood coagulation for protease nexin 2. 

Kaplan KL. Platelet granule proteins localization and secretion, In Gordon AS, ed, Platelet in Biology and Pathology. Vol, 5, Amsterdam Elsevier, 1981 77. 

Kapp, A. (1993) The role of eosinophils in the pathogenesis of atopic dermatitis— eosinophil granule proteins as markers of disease activity. Allergy 48,1-5. 

Rosenberg, H. F. and Tiffany, H. L. (1994) Characterization of the eosinophil granule proteins recognized by the activation-specific antibody EG2. J. Leukoc. Biol. 56, 502-506. 

Scofield, J. D., and Greenwell, P. 1987. Wheat starch granule proteins and their technological significance. In "Cereals in a European Context. Proc. First Conference on Food Science and Technology" (I. D. Morton, ed.), pp. 407-419. Ellis Horwood Publishers City, St. 

KAHAN KL, BROEKMAN MJ, CHERNOFF a, LeSZNK GR, DRE.LINGS M. Platelet alpha-granule proteins -studies on release and subcellular localization. Blood 53 604-618,1979. 

SCHMAIER AH, Smith PM, COLMAN RW. Platelet Cl inhibitor. A secreted alpha granule protein. JClin Invest 7S 242-250,1985. 

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